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For better understanding of its potential toxicities, TDCIPP (250, 500, or 650 mg\/kg\/day) or vehicle control was administrated orally to adult male Wistar\u2010Imamichi rats for 7 days. After the final administration of compounds, organ weights, histopathology, blood biochemistry, and hematology were examined. Hepatic toxicity was observed at doses \u2265 500 mg\/kg\/day of TDCIPP, and renal toxicity was observed at 650 mg\/kg\/day. The anti\u2010androgenic activity of TDCIPP was previously confirmed in vitro and in vivo, but weights of epididymis, an androgen\u2010dependent organ, were not affected by TDCIPP treatment in adults. Serum alkaline phosphatase activity was significantly decreased in all TDCIPP\u2010treated rats independent of dose. Hemoglobin concentration, hematocrit, red blood cell count, and reticulocyte count were decreased in all TDCIPP\u2010treated rats, but mean corpuscular volume, total iron\u2010binding capacity, and serum iron were normal, suggesting that renal anemia was caused by TDCIPP. Together with previous reports on effects of anti\u2010androgenic substances on red blood cell indices, anemia caused by TDCIPP could be due to its anti\u2010androgenic activity. These considerations will contribute to further assessment of the toxicity of the compound.<\/jats:p>","DOI":"10.1002\/jat.4075","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T06:05:07Z","timestamp":1601445907000},"page":"987-992","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Novel toxicity of tris(1,3\u2010dichloro\u20102\u2010propyl) phosphate in adult male rats"],"prefix":"10.1002","volume":"41","author":[{"given":"Shohei","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Organization for the Strategic Coordination of Research and Intellectual Property Meiji University  Kawasaki Japan"},{"name":"Lab of Animal Behavior and Environmental Science, School of Agriculture Meiji University  Kawasaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kodai","family":"Abe","sequence":"additional","affiliation":[{"name":"Lab of Animal Behavior and 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