{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T08:46:37Z","timestamp":1768898797222,"version":"3.49.0"},"reference-count":61,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T00:00:00Z","timestamp":1601856000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K09121"],"award-info":[{"award-number":["16K09121"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We compared the toxicokinetics of methylmercury (MeHg) in KK\u2010Ay type 2 diabetic mice and C57BL\/6J mice to evaluate how metabolic changes associated with diabetes affect MeHg toxicokinetics. A single dose of MeHg (0.2, 1, or 5 mg mercury\/kg) was administered orally to 12\u2010week\u2010old KK\u2010Ay and C57BL\/6J male mice. Total mercury concentrations in plasma, blood cells, whole blood, and tissues (brain, kidneys, liver, and pancreas) were measured after 4, 7, 11, and 14 days. The volume of distribution\/bioavailability and the elimination rate constant per day were higher in KK\u2010Ay mice, while the terminal elimination half\u2010life was lower in almost all samples of KK\u2010Ay mice. The area under the curve was lower in all blood and almost all tissue samples from KK\u2010Ay mice. Total clearance\/bioavailability was lower in all blood and tissue samples of KK\u2010Ay mice at all MeHg doses. These results indicate that MeHg is more rapidly absorbed by, and eliminated from, the blood cells, brain, liver, kidney, and pancreas of KK\u2010Ay mice under the experimental conditions. Different patterns of tissue\u2010to\u2010plasma and tissue\u2010to\u2010whole blood partition coefficients suggest that notable differences in MeHg transfer between plasma and blood cells affect its distribution in tissues of the two mouse strains. These findings are useful to understand the selective distribution of MeHg to target organs and the sensitivity to MeHg in pathological states.<\/jats:p>","DOI":"10.1002\/jat.4078","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T03:41:41Z","timestamp":1601869301000},"page":"928-940","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Toxicokinetics of methylmercury in diabetic KK\u2010Ay mice and C57BL\/6 mice"],"prefix":"10.1002","volume":"41","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4301-3827","authenticated-orcid":false,"given":"Megumi","family":"Yamamoto","sequence":"first","affiliation":[{"name":"Department of Environment and Public Health National Institute for Minamata Disease  Minamata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8488-3821","authenticated-orcid":false,"given":"Rie","family":"Yanagisawa","sequence":"additional","affiliation":[{"name":"Center for Health and Environmental Risk Research National Institute for Environmental Studies  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Sakai","sequence":"additional","affiliation":[{"name":"nippon medac Co., Ltd.  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0275-9198","authenticated-orcid":false,"given":"Masaki","family":"Mogi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Ehime University Graduate School of Medicine  Toon Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7850-8064","authenticated-orcid":false,"given":"Satoshi","family":"Shuto","sequence":"additional","affiliation":[{"name":"Department of Molecular Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences Hokkaido University  Sapporo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masachika","family":"Shudo","sequence":"additional","affiliation":[{"name":"Advanced Research Support Center Ehime University  Matsuyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazuki","family":"Kashiwagi","sequence":"additional","affiliation":[{"name":"Department of Environment and Public Health National Institute for Minamata Disease  Minamata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megumi","family":"Kudo","sequence":"additional","affiliation":[{"name":"Department of Environment and Public Health National Institute for Minamata Disease  Minamata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaaki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine National Institute for Minamata Disease  Minamata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1951-4541","authenticated-orcid":false,"given":"Mineshi","family":"Sakamoto","sequence":"additional","affiliation":[{"name":"Department of Environment and Public Health National Institute for Minamata Disease  Minamata Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/00039896.1969.10666872"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3945\/an.111.000737"},{"key":"e_1_2_8_4_1","unstructured":"Agency for Toxic Substances and Disease Registry. 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