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However, the biotoxicity of multi\u2010component PAHs from atmospheric pollutants has been poorly studies. The main topic of this study was to investigate the PAHs mixture, which derived from atmospheric pollutants, induced toxic effects and inflammatory effects on human bronchial epithelial cells in vitro. The results showed that PAHs mixture could decrease the cell viability, increase the apoptosis rate, and induce cell cycle arrest at S\u2010phase. Furthermore, the expression of inflammatory factors IL\u20101\u03b2 and IL\u20106 were increased and NF\u2010\u03baB signaling pathway was activated in PAHs mixture\u2010treated cells. The findings of this study indicate that PAHs mixture\u2010induced cytotoxicity and inflammation may be related to intracellular ROS generation and to the activated NF\u2010\u03baB signaling pathway.<\/jats:p>","DOI":"10.1002\/jat.4164","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T21:35:45Z","timestamp":1617053745000},"page":"1803-1815","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Cytotoxicity and inflammatory effects in human bronchial epithelial cells induced by polycyclic aromatic hydrocarbons mixture"],"prefix":"10.1002","volume":"41","author":[{"given":"Hong","family":"Wang","sequence":"first","affiliation":[{"name":"Lab for Bone Metabolism, Xi'an Key Laboratory of Special Medicine and Health Engineering, Key Lab for Space Biosciences and Biotechnology, Research Center for Special Medicine and Health Systems Engineering, NPU\u2010UAB Joint Laboratory for Bone 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