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Although exposure to polychlorinated (PC) DD\/DFs induces toxic effects, including liver injury and neurobehavioral disorder, little is known about toxicities associated with PBDD\/DF exposure. Thus, we examined effects of perinatal exposure to brominated congener on the infant mouse. Gene expression in several organs, such as the liver and brain, was analyzed in mouse offspring born to dams administered 2,3,7,8\u2010tetrabromodibenzofuran (TBDF; 9 or 45\u2009\u03bcg\/kg body weight) or 2,3,7,8\u2010tetrachlorodibenzo\u2010<jats:italic>p<\/jats:italic>\u2010dioxin (TCDD; 3\u2009\u03bcg\/kg body weight) on gestational day 12.5. An increase in liver size was observed in TBDF\u2010 or TCDD\u2010exposed offspring in infancy. Gene microarray analysis revealed that 163 and 36 genes were markedly upregulated and downregulated, respectively, in the liver of TBDF\u2010exposed mice compared with those in vehicle\u2010treated mice on postnatal day (PND) 5. Significant increases in <jats:italic>Cyp1a1<\/jats:italic>, <jats:italic>Cyp1a2<\/jats:italic>, <jats:italic>Fmo3<\/jats:italic>, and <jats:italic>Pnliprp1<\/jats:italic> and decreases in <jats:italic>Tff3<\/jats:italic>, <jats:italic>Ocstamp<\/jats:italic>, <jats:italic>Kcnk16<\/jats:italic>, and <jats:italic>Lgals2<\/jats:italic> mRNA levels in TBDF\u2010exposed offspring on PNDs 5 and 12 were confirmed by quantitative PCR. In particular, a significant reduction in <jats:italic>Tff3<\/jats:italic> mRNA in the liver, but not in the brain, small intestine, colon, and kidney, was observed in offspring perinatally exposed to TBDF or TCDD. Ultrasonic calls of TBDF\u2010 or TCDD\u2010exposed offspring on PNDs 3\u20135 were impaired. Taken together, perinatal exposure to polyhalogenated dioxin\/furan congeners disrupts gene expression patterns in the liver and ultrasonic calling during infancy. These results suggest that liver injury may contribute to neurobehavioral disorder.<\/jats:p>","DOI":"10.1002\/jat.4220","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:19Z","timestamp":1626134419000},"page":"305-317","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Liver\u2010specific decrease in <i>Tff3<\/i> gene expression in infant mice perinatally exposed to 2,3,7,8\u2010tetrabromodibenzofuran or 2,3,7,8\u2010tetrachlorodibenzo\u2010<i>p<\/i>\u2010dioxin"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7164-8099","authenticated-orcid":false,"given":"Eiki","family":"Kimura","sequence":"first","affiliation":[{"name":"Center for Health and Environmental Risk Research National Institute for Environmental Studies  Tsukuba Japan"},{"name":"Japan Society for the Promotion of Science  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Go","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Center for Material Cycles and Waste Management Research National Institute for Environmental Studies  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Uramaru","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Nihon Pharmaceutical University  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaki","family":"Kakeyama","sequence":"additional","affiliation":[{"name":"Faculty of Human Sciences Waseda University  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1762-8270","authenticated-orcid":false,"given":"Fumihiko","family":"Maekawa","sequence":"additional","affiliation":[{"name":"Center for Health and Environmental Risk Research National Institute for Environmental Studies  Tsukuba Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00293624"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2009.12.007"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-005-5480-x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(91)90338-F"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041-008X(85)90329-1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-015-1456-2"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1515\/BC.2009.138"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000490039"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3176"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/es0258780"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2013.03.086"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1997.8261"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00184.2011"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2004.12.003"},{"issue":"10","key":"e_1_2_9_16_1","first-page":"2265","article-title":"Gene expression and cell proliferation in rat liver after 2,3,7,8\u2010tetrachlorodibenzo\u2010p\u2010dioxin exposure","volume":"53","author":"Fox T. 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