{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T16:52:16Z","timestamp":1776185536904,"version":"3.50.1"},"reference-count":51,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2022,3,18]],"date-time":"2022-03-18T00:00:00Z","timestamp":1647561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012546","name":"Chongqing Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["XmT2020194"],"award-info":[{"award-number":["XmT2020194"]}],"id":[{"id":"10.13039\/100012546","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21874095"],"award-info":[{"award-number":["21874095"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Quantum dots (QDs), with unique and tunable optical properties, have been widely used in many fields closely related to our daily lives, such as biomedical application and electronic products. Therefore, the potential toxicity of QDs on the human health should be understood. Autophagy plays an important role in cell survival and death. Endoplasmic reticulum autophagy (ER\u2010phagy), a selective autophagy that degrades ER, responds to the accumulation of misfolded proteins and ER stress. Although many reports have revealed that autophagy can be disturbed by cadmium telluride (CdTe)\u2010QDs and other nanomaterials, there are still lack more detailed researches to illustrate the function of autophagy in CdTe\u2010QDs\u2010treated cells, and the function of ER\u2010phagy in CdTe\u2010QDs\u2010treated cells remains to be illustrated. On the basis of transcriptome analysis, we explored the effect of CdTe\u2010QDs on <jats:styled-content style=\"fixed-case\">Saccharomyces cerevisiae<\/jats:styled-content> and first illustrated that both of autophagy and ER\u2010phagy were protective mechanisms in CdTe\u2010QDs\u2010treated cells. It was found that CdTe\u2010QDs inhibited the proliferation of yeast cells, disrupted homeostasis of cells, membrane integrity, and metabolism process. All of these can be reasons of the reduction of cell viability. The abolishment of autophagy and ER\u2010phagy reduce the cell survival, indicating both of them are cell protective mechanisms against CdTe\u2010QDs toxicity in yeast cells. Therefore, our data are significant for the application of CdTe\u2010QDs and provide precious information for understanding of nanomaterials\u2010related ER\u2010phagy.<\/jats:p>","DOI":"10.1002\/jat.4282","type":"journal-article","created":{"date-parts":[[2022,1,5]],"date-time":"2022-01-05T21:02:56Z","timestamp":1641416576000},"page":"1146-1158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Induction of autophagy and endoplasmic reticulum autophagy caused by cadmium telluride quantum dots are protective mechanisms of yeast cell"],"prefix":"10.1002","volume":"42","author":[{"given":"Fujing","family":"Wei","sequence":"first","affiliation":[{"name":"Research Center of Analytical Instrumentation, Key Laboratory of Bio\u2010resource and Eco\u2010environment, Ministry of Education, College of Life Sciences Sichuan University  Chengdu China"},{"name":"School of Life Sciences Chongqing University  Chongqing 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