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However, their biosafety assessment lags far behind their rapid application. In this study, we observed that CdTe quantum dots with certain exposed doses and time decreased the cell viability and increased the apoptosis rates in ND7\/23 cells. In general, CdTe quantum dots exposure could promote the accumulation of reactive oxygen species (ROS) in cells and decrease the mitochondrial membrane potential, which led to pathological changes and subcellular organelle damages. We hypothesized that the mitochondrial pathway could be involved in CdTe quantum dots\u2010induced apoptosis. The results suggested that CdTe quantum dots exposure increased the expression levels of three mitochondrial pathway markers, for example, caspase\u20103, cytochrome c, and Bax while decreased Bcl\u20102 protein expression, following with cytochrome c falling out of the inner membrane of mitochondrial and releasing into the cytoplasm. The application of caspase\u20103 protein inhibitor Ac\u2010DEVD\u2010CHO could decrease apoptosis rates in ND7\/23 cells. The results, taken together, demonstrated that CdTe quantum dots could induce apoptosis of ND7\/23 cells through the mitochondrial pathway. Our findings provide a novel insight for researchers to explore CdTe quantum dots' toxic mechanisms to reduce their adverse effects.<\/jats:p>","DOI":"10.1002\/jat.4291","type":"journal-article","created":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T01:54:45Z","timestamp":1643248485000},"page":"1218-1229","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["The apoptosis induced by CdTe quantum dots through the mitochondrial pathway in dorsal root ganglion cell line ND7\/23"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4650-4741","authenticated-orcid":false,"given":"Changcun","family":"Bai","sequence":"first","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health Southeast University  Nanjing 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