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E171 is accumulated in some organs triggering toxicity, but the effects on the blood parameters after oral consumption have been less studied. Recently, evidence shows that oral exposure to E171 induces behavioral signs of anxiety and depression. The relation between blood alterations and psychiatric disorders has been previously demonstrated. However, the oral exposure to E171 effects on alterations in blood parameters and effects linked to alterations in animal behavior has not been explored. In this short communication, we aimed to investigate the effects of E171 on specific blood parameters (hematocrit, hemoglobin, number of erythrocytes, and leukocytes) and anxiety and compulsive\u2010like behavior in males and females orally exposed to ~5\u2009mg\/kg for 4\u2009weeks. The results showed that E171 decreased hematocrit and hemoglobin in male but not in female mice while leukocyte and erythrocyte count remained unaltered. Oral consumption of E171 decreased the levels of anxiety\u2010like behavior in females but not in male mice, while compulsive\u2010like behavior was increased in both male and female mice.<\/jats:p>","DOI":"10.1002\/jat.4296","type":"journal-article","created":{"date-parts":[[2022,2,6]],"date-time":"2022-02-06T20:33:45Z","timestamp":1644179625000},"page":"1411-1419","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Food\u2010grade titanium dioxide decreases hematocrit and hemoglobin and increases compulsive\u2010like behavior in male mice"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6658-2870","authenticated-orcid":false,"given":"Estefany I.","family":"Medina\u2010Reyes","sequence":"first","affiliation":[{"name":"Departamento de Biolog\u00eda, Facultad de Qu\u00edmica Universidad Nacional Aut\u00f3noma de M\u00e9xico  Ciudad de M\u00e9xico 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