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The aim of this study was to establish the cause\u2013effect relationship between renal tubular dysfunction and cancer mortality in the general population in non\u2010contaminated areas. A 19\u2010year cohort study was conducted in 1110 men and 1703 women in 1993 or 1994, who lived in three cadmium\u2010non\u2010contaminated areas. Mortality risk ratios of urinary \u03b22\u2010microglobulin (\u03b22MG) and <jats:italic>N<\/jats:italic>\u2010acetyl\u2010\u03b2\u2010glucosaminidase (NAG) for all malignant neoplasms and specific cancers were estimated using the Fine and Gray competing risks regression model. Significant hazard ratios (HRs) for liver and pancreas cancer were observed for NAG (liver: HR corresponding to an increase of 1\u00a0IU\/g cr, 1.10, 95%CI, 1.02\u20131.19, pancreas: HR, 1.10, 95%CI, 1.02\u20131.19) in men. In women, a negative HR was observed for NAG (lung cancer: HR 0.80, 95% CI, 0.67\u20130.96) and for \u03b22MG (all malignant neoplasms: HR, 0.97, 95% CI, 0.93\u20131.00). The present study indicated that renal tubular dysfunction was significantly related to mortality in the general population of cadmium\u2010non\u2010contaminated areas in Japan.<\/jats:p>","DOI":"10.1002\/jat.4304","type":"journal-article","created":{"date-parts":[[2022,2,19]],"date-time":"2022-02-19T03:09:30Z","timestamp":1645240170000},"page":"1458-1466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Renal tubular dysfunction and cancer mortality in the Japanese general population living in cadmium\u2010non\u2010contaminated areas"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8034-2243","authenticated-orcid":false,"given":"Kazuhiro","family":"Nogawa","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuuka","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Sakuma","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4929-3225","authenticated-orcid":false,"given":"Masaru","family":"Sakurai","sequence":"additional","affiliation":[{"name":"Department of Hygiene Kanazawa Medical University  Uchinada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneko","family":"Nishijo","sequence":"additional","affiliation":[{"name":"Department of Public Health Kanazawa Medical University  Uchinada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masao","family":"Ishizaki","sequence":"additional","affiliation":[{"name":"Department of Hygiene Kanazawa Medical University  Uchinada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Morikawa","sequence":"additional","affiliation":[{"name":"Department of Public Health Kanazawa Medical University  Uchinada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruhiko","family":"Kido","sequence":"additional","affiliation":[{"name":"Department of Community Health Nursing Kanazawa University School of Health Sciences  Kanazawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideaki","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Medical Research Institute Kanazawa Medical University  Uchinada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3612-2395","authenticated-orcid":false,"given":"Yasushi","family":"Suwazono","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Graduate School of Medicine Chiba University  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,3]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004200000225"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2007.07.007"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)51334-5"},{"key":"e_1_2_8_5_1","unstructured":"Center for Cancer Control and Information Services of National Cancer Center. 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