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Over usage and ultimate disposal of metallic particles from the industries subsequently lead to pollution of the aquatic environment. Exposure of NPs in aquatic ecosystem alters biological and physicochemical parameters of the water and aquatic organisms and determines their potential ecotoxicological impacts. Prolonged exposure of aquatic organisms to these NPs results in differential bioaccumulation and distribution into internal organs like liver, kidney, gills, brain, and muscle tissue. The contact of NPs to aquatic organisms induces various types of toxic traits including cytotoxicity, genotoxicity, and epigeneticity. Taking this in consideration, this present review focuses on the comparative toxic impact of ZnO and Ag NPs towards both vertebrates and invertebrates in aquatic ecosystems.<\/jats:p>","DOI":"10.1002\/jat.4310","type":"journal-article","created":{"date-parts":[[2022,2,25]],"date-time":"2022-02-25T01:29:54Z","timestamp":1645752594000},"page":"1890-1900","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":56,"title":["Comparative evaluation on the toxic effect of silver (Ag) and zinc oxide (ZnO) nanoparticles on different trophic levels in aquatic ecosystems: A review"],"prefix":"10.1002","volume":"42","author":[{"given":"Ashokkumar","family":"Sibiya","sequence":"first","affiliation":[{"name":"Nanobiosciences and Nanopharmacology Division, Biomaterials and Biotechnology in Animal Health Lab, Department of Animal Health and Management, Science Campus 6th Floor Alagappa University  Karaikudi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeyaraj","family":"Jeyavani","sequence":"additional","affiliation":[{"name":"Nanobiosciences and Nanopharmacology Division, Biomaterials and Biotechnology in Animal Health Lab, Department of Animal Health and Management, Science Campus 6th Floor Alagappa University  Karaikudi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perumal","family":"Santhanam","sequence":"additional","affiliation":[{"name":"Marine Planktonology and Aquaculture Laboratory, Department of Marine Science Bharathidasan University  Tiruchirappalli India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elumalai","family":"Preetham","sequence":"additional","affiliation":[{"name":"Department of Marine Biology, Microbiology and Biochemistry, School of Marine Sciences Cochin University of Science and Technology (CUSAT), Lakeside Campus Fine Arts Avenue Cochin  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Freitas","sequence":"additional","affiliation":[{"name":"Department of Biology &amp; Centre for Environmental and Marine Studies (CESAM) University of Aveiro  Aveiro Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7889-0363","authenticated-orcid":false,"given":"Baskaralingam","family":"Vaseeharan","sequence":"additional","affiliation":[{"name":"Nanobiosciences and Nanopharmacology Division, Biomaterials and Biotechnology in Animal Health Lab, Department of Animal Health and Management, Science Campus 6th Floor Alagappa University  Karaikudi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10661-008-0624-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2012.07.012"},{"key":"e_1_2_8_4_1","first-page":"259","article-title":"Stable silver nanoparticle synthesizing methods and its applications","volume":"1","author":"Arasu T. 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