{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:31:13Z","timestamp":1790109073530,"version":"4.0.1"},"reference-count":102,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,5]],"date-time":"2022-05-05T00:00:00Z","timestamp":1651708800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82173545"],"award-info":[{"award-number":["82173545"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31671034"],"award-info":[{"award-number":["31671034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21876026"],"award-info":[{"award-number":["21876026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>In vivo<\/jats:italic> toxicological studies are currently necessary to analyze the probable dangers of quantum dots (QDs) to the environment and human safety, due to the fast expansion of QDs in a range of applications. Because of its high fecundity, cost\u2010effectiveness, well\u2010defined developmental phases, and optical transparency, zebrafish has long been considered the \u201cgold standard\u201d for biosafety assessment of chemical substances and pollutants. In this review, the advantages of using zebrafish in QD toxicity assessment were explored. Then, the target organ toxicities such as developmental toxicity, immunotoxicity, cardiovascular toxicity, neurotoxicity, and hepatotoxicity were summarized. The hazardous effects of different QDs, including cadmium\u2010containing QDs like CdTe, CdSe, and CdSe\/ZnS, as well as cadmium\u2010free QDs like graphene QDs (GQDs), graphene oxide QDs (GOQDs), and others, were emphasized and described in detail, as well as the underlying mechanisms of QDs generating these effects. Furthermore, general physicochemical parameters determining QD\u2010induced toxicity in zebrafish were introduced, such as chemical composition and surface coating\/modification. The limitations and special concerns of using zebrafish in QD toxicity studies were also mentioned. Finally, we predicted that the utilization of high\u2010throughput screening assays and omics, such as transcriptome sequencing, proteomics, and metabolomics will be popular topic in nanotoxicology.<\/jats:p>","DOI":"10.1002\/jat.4333","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T02:19:07Z","timestamp":1650421147000},"page":"89-106","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Progress on the toxicity of quantum dots to model organism\u2010zebrafish"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4650-4741","authenticated-orcid":false,"given":"Changcun","family":"Bai","sequence":"first","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4921-9735","authenticated-orcid":false,"given":"Meng","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,5]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.271.5251.933"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3910"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr098"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2019.04.082"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.9b00335"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2017.05.173"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3109\/17435390.2015.1005032"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep26078"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/NPHOTON.2013.181"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-021-00571-5"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2020.103426"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23157"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.2406"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/398_2018_15"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.03.028"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhazmat.2018.05.063"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.202003912"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201805087"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-013-1700-8"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/26\/21\/215703"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.10.004"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.03.009"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2020.128170"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.0c01335"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn102734s"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3390\/nano8070561"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12274-017-1616-1"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2014.01.006"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3745"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1116"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12111"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2018.11.053"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201400011"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.08.022"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0144906"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2016.12.008"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408444.2017.1404965"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep11835"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.7b04668"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1021\/es801925c"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/bit.21564"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2018.11.118"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.3109\/17435390.2013.822116"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2021.105813"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11051-011-0597-3"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1nr10319a"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9nh00476a"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2018-0010"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201202115"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5b06710"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.0c17492"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1039\/c9nr09524a"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4627"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2019.124588"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.7b03283"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4614-0106-3_15"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-017-2211-6"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7nr03026f"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12953-015-0072-7"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.14573\/altex.1601281"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2020.02.002"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2017.12.019"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2012.08.003"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201700595"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2016.09.021"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2018.04.206"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4nr07005d"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.4266"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8cc08610a"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.4055"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2015.11.021"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.200600317"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2014.02.011"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1039\/d0nr07245a"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3mt20234h"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2013.07.087"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1063654"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2018.10.092"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-010-0627-4"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8sc03510e"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aquatox.2015.11.019"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3288"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2019.05.022"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2017.12.334"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.3967\/bes2015.048"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b00074"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2021.112022"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1021\/es304987r"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.0c07688"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2018.05.014"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrev.6b00290"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.3944"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.analchem.9b00517"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.1117\/12.2537097"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.8b04235"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2cs35392j"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04635-5"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2015.12.077"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2017.04.026"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2012.04.012"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1039\/d1qm00193k"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jes.2020.07.019"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.4333","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jat.4333","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.4333","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T16:08:46Z","timestamp":1760544526000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.4333"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,5]]},"references-count":102,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,1]]}},"alternative-id":["10.1002\/jat.4333"],"URL":"https:\/\/doi.org\/10.1002\/jat.4333","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,5]]},"assertion":[{"value":"2022-03-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}