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Two types of cell death, including apoptosis and autophagy, as well as two important organelles, mitochondria and endoplasmic reticulum, were focused after CdTe QDs exposure. The results showed that CdTe QDs induced apoptosis in RSC96 cells in a concentration\u2010dependent manner; promoted the accumulation of intracellular reactive oxygen species; decreased the mitochondrial membrane potential; caused the release of cytochrome c; and also increased the expression of Bcl\u20102 associated X protein, caspase\u20103, and cytochrome c proteins and decreased the expression of Bcl\u20102 protein. Further results also confirmed that CdTe QDs could be internalized by RSC96 cells, and the exposure and internalization of CdTe QDs could induce excessive endoplasmic reticulum stress in the cells, and the expression levels of binding immunoglobulin protein, C\/EBP homologous protein, and caspase12 proteins were increased in a concentration\u2010dependent manner. Moreover, autophagy\u2010related proteins LC3II, Beclin1, and P62 all increased after CdTe QDs exposure, suggesting that CdTe QDs exposure both promoted autophagosome formation and inhibited autophagosome degradation, and that CdTe QDs affected the autophagic flow in RSC96 cells. In conclusion, CdTe QDs are able to cause apoptosis and autophagy in RSC96 cells through mitochondrial and endoplasmic reticulum stress pathways, and the possible neurotoxicity of CdTe QDs should be further investigated.<\/jats:p>","DOI":"10.1002\/jat.4367","type":"journal-article","created":{"date-parts":[[2022,7,20]],"date-time":"2022-07-20T12:03:15Z","timestamp":1658318595000},"page":"1962-1977","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["CdTe quantum dots trigger oxidative stress and endoplasmic reticulum stress\u2010induced apoptosis and autophagy in rat Schwann cell line RSC96"],"prefix":"10.1002","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4650-4741","authenticated-orcid":false,"given":"Changcun","family":"Bai","sequence":"first","affiliation":[{"name":"Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, School of Public Health Southeast University  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