{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T04:38:52Z","timestamp":1787978332443,"version":"build-2784847793"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,11,26]],"date-time":"2022-11-26T00:00:00Z","timestamp":1669420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Amiodarone (AMD) is an antiarrhythmic drug prescribed to treat ventricular tachycardia and fibrillation. However, it causes an unpredictable toxicity (idiosyncratic), which may depend on co\u2010exposure to pollutants. AMD toxicity involves calcium homeostasis alteration and oxidative stress, which are also affected by cigarette smoke (CS). We investigated the interaction of CS\u2010condensate (CSC), phenanthrene, and benzo(a)pyrene with AMD toxicity on <jats:styled-content style=\"fixed-case\"><jats:italic>Saccharomyces cerevisiae<\/jats:italic><\/jats:styled-content>. AMD toxicity was reduced by CSC or phenanthrene. Benzo(a)pyrene mildly decreased AMD toxicity on the wild\u2010type strain, but not on the catalase\u2010CTT1 mutant. This latter and other mutants in glucose receptor\u2010GPR1 or calcium transporter\u2010PMR1 showed lower antagonistic effect to AMD by CSC or phenanthrene relative to the wild type, suggesting roles of oxidative stress, calcium homeostasis, and hexose\u2010sensing in this interaction.<\/jats:p>","DOI":"10.1002\/jat.4413","type":"journal-article","created":{"date-parts":[[2022,11,7]],"date-time":"2022-11-07T13:43:56Z","timestamp":1667828636000},"page":"764-768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cigarette smoke interacts with amiodarone toxicity in <scp><i>Saccharomyces cerevisiae<\/i><\/scp>"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0172-6172","authenticated-orcid":false,"given":"Houssein","family":"Al\u2010Attrache","sequence":"first","affiliation":[{"name":"EDST and FS1 Lebanese University, Rafic Hariri Campus  Beirut Lebanon"},{"name":"Faculty of Sciences\u2010III Lebanese University  Tripoli Lebanon"},{"name":"Faculty of Public Health, Section IV Lebanese University  Zahleh Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Halloum","sequence":"additional","affiliation":[{"name":"EDST and FS1 Lebanese University, Rafic Hariri Campus  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lara","family":"Hammoud","sequence":"additional","affiliation":[{"name":"Faculty of Sciences\u2010III Lebanese University  Tripoli Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"El Ghoz","sequence":"additional","affiliation":[{"name":"EDST and FS1 Lebanese University, Rafic Hariri Campus  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5807-2707","authenticated-orcid":false,"given":"Ziad","family":"Abdel\u2010Razzak","sequence":"additional","affiliation":[{"name":"EDST and FS1 Lebanese University, Rafic Hariri Campus  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2017.1320404"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.15698\/mic2018.03.618"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10142-002-0058-2"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303300200"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2005.10.122"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/omi.2010.0029"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.01.004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/qjmed\/hcg138"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2019.02.009"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1567-1364.2009.00538.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0155791"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1089\/aivt.2016.0039"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/01480545.2019.1659809"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2018.08.005"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12192-016-0667-7"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.26402\/jpp.2020.5.08"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707593200"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.12122\/j.issn.1673-4254.2021.03.13"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.4413","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jat.4413","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.4413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T17:51:14Z","timestamp":1760550674000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.4413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,26]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1002\/jat.4413"],"URL":"https:\/\/doi.org\/10.1002\/jat.4413","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,26]]},"assertion":[{"value":"2022-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-03","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}