{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T01:43:27Z","timestamp":1787103807579,"version":"build-2736575974"},"reference-count":73,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2023,1,22]],"date-time":"2023-01-22T00:00:00Z","timestamp":1674345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/00164\u20100"],"award-info":[{"award-number":["2019\/00164\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Cyclodextrins are nanometric cyclic oligosaccharides with amphiphilic characteristics that increase the stability of drugs in pharmaceutical forms and bioavailability, in addition to protecting them against oxidation and UV radiation. Some of their characteristics are low toxicity, biodegradability, and biocompatibility. They are divided into \u03b1\u2010, \u03b2\u2010, and \u03b3\u2010cyclodextrins, each with its own particularities. They can undergo surface modifications to improve their performances. Furthermore, their drug inclusion complexes can be made by various methods, including lyophilization, spray drying, magnetic stirring, kneading, and others. Cyclodextrins can solve several problems in drug stability when incorporated into dosage forms (including tablets, gels, films, nanoparticles, and suppositories) and allow better topical biological effects of drugs at administration sites such as skin, eyeballs, and oral, nasal, vaginal, and rectal cavities. However, as they are nanostructured systems and some of them can cause mild toxicity depending on the application site, they must be evaluated for their nanotoxicology and nanosafety aspects. Moreover, there is evidence that they can cause severe ototoxicity, killing cells from the ear canal even when applied by other administration routes. Therefore, they should be avoided in otologic administration and should have their permeation\/penetration profiles and the in vivo hearing system integrity evaluated to certify that they will be safe and will not cause hearing loss.<\/jats:p>","DOI":"10.1002\/jat.4429","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T06:43:45Z","timestamp":1672296225000},"page":"1410-1420","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Biopharmaceutical and nanotoxicological aspects of cyclodextrins for non\u2010invasive topical treatments: A critical review"],"prefix":"10.1002","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2370-0662","authenticated-orcid":false,"given":"Bruno Vincenzo Fiod","family":"Riccio","sequence":"first","affiliation":[{"name":"Department of Drugs and Medicines, School of Pharmaceutical Sciences S\u00e3o Paulo State University (UNESP)  Araraquara Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9ia Bagliotti","family":"Meneguin","sequence":"additional","affiliation":[{"name":"Department of Drugs and Medicines, School of Pharmaceutical Sciences S\u00e3o Paulo State University (UNESP)  Araraquara Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franciele Garcia","family":"Baveloni","sequence":"additional","affiliation":[{"name":"Department of Drugs and Medicines, School of Pharmaceutical Sciences S\u00e3o Paulo State University (UNESP)  Araraquara Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Aenishanslin","family":"de Antoni","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Ponta Grossa State University (UEPG)  Ponta Grossa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leda Maria Gorla","family":"Robusti","sequence":"additional","affiliation":[{"name":"Department of Drugs and Medicines, School of Pharmaceutical Sciences S\u00e3o Paulo State University (UNESP)  Araraquara Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Palmira Daflon","family":"Gremi\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Drugs and Medicines, School of Pharmaceutical Sciences S\u00e3o Paulo State University (UNESP)  Araraquara Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priscileila Colerato","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Ponta Grossa State University (UEPG)  Ponta Grossa Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlus","family":"Chorilli","sequence":"additional","affiliation":[{"name":"Department of Drugs and Medicines, School of Pharmaceutical Sciences S\u00e3o Paulo State University (UNESP)  Araraquara Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5260976"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.183"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.procbio.2010.07.027"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22091475"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14010118"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2019.101475"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425240903222218"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.20350"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25040998"},{"issue":"1","key":"e_1_2_8_11_1","first-page":"68","article-title":"Cyclodextrin inclusion complex to enhance solubility of poorly water soluble drugs: A review","volume":"4","author":"Chaudhary V. B.","year":"2013","journal-title":"International Journal of Pharmaceutical Sciences and Research"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12989-022-00489-4"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-015-0528-6"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00355"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10973-021-10958-1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2018.11.023"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2020.108073"},{"key":"e_1_2_8_18_1","unstructured":"European Medicines Agency. (2014).Background review for cyclodextrins used as excipients. 44(November) 12\u201316. Retrieved fromwww.ema.europa.eu\/contact"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxres\/tfab040"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.21577\/1984-6835.20190040"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.09.025"},{"key":"e_1_2_8_22_1","unstructured":"Grosrey J.(1996).No \u4e3b\u89b3\u7684\u5065\u5eb7\u611f\u3092\u4e2d\u5fc3\u3068\u3057\u305f\u5728\u5b85\u9ad8\u9f62\u8005\u306b\u304a\u3051\u308b \u5065\u5eb7\u95a2\u9023\u6307\u6a19\u306b\u95a2\u3059\u308b\u5171\u5206\u6563\u69cb\u9020\u5206\u6790Title. Portaria N\u00b0 146 de 07 de Mar\u00e7o de 1996 (19) 219."},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1039\/c5ra04305k"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2018.11.012"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2012.11.020"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2016.03.009"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2017.1386733"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1021\/js960213f"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ddr.21452"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2017.11.018"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/19476337.2019.1612948"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2011.593728"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10847-009-9560-7"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S91216"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-020-06075-y"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00253-009-2221-3"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.05.013"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0175236"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2018.00448"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.3906\/KIM-1910-43"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2017.11.016"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/942916"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.21793"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2013.05.084"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.04.071"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/604690"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.07.075"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2015.01.058"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.4236\/pp.2015.65027"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13060915"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biortech.2013.05.087"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13030417"},{"issue":"3","key":"e_1_2_8_53_1","first-page":"255","article-title":"Cyclodextrins and their derivatives in drug delivery: A review","volume":"6","author":"Palem C. R.","year":"2012","journal-title":"Current Trends in Biotechnology and Pharmacy"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-018-0392-8"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2019.110382"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.3390\/polysaccharides3010001"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119579"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190306163602"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.3390\/oxygen2040039"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2014.938839"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.201901862"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/15376516.2019.1566425"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639040601150195"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.4103\/0975-7406.67003"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-007-9395-0"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2013.04.035"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2015.10.042"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-015-9814-9"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2018.1425426"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1023\/B:PHAM.0000032998.84488.7a"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/14658011.2018.1475166"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.04.115"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.9b14075"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17134657"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.4429","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jat.4429","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.4429","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T13:50:45Z","timestamp":1760536245000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.4429"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,22]]},"references-count":73,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/jat.4429"],"URL":"https:\/\/doi.org\/10.1002\/jat.4429","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,22]]},"assertion":[{"value":"2022-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-27","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}