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In our study, we aimed to determine the CPZ\u2010induced changes in some members of the heat shock protein family in rat hearts and further explore the possible mechanisms of CPZ\u2010induced cardiotoxicity. Twenty\u2010four Sprague Dawley rats were randomly divided into three groups (<jats:italic>n<\/jats:italic>\u2009=\u20098 per group): control, low dose (33.216\u2009mg\/kg) and high dose (94.211\u2009mg\/kg). CPZ administration induced hypothermia in rats. Pathological changes, including ischaemia and hypoxia, were observed in rat hearts. Furthermore, the serum levels of cardiac Troponin T (c\u2010TN\u2010T) and brain natriuretic peptide (BNP) were elevated in the CPZ\u2010exposed groups. Meanwhile, the protein and gene expression of HSP70, HSP60, HSP27 and HSP10 significantly differed between the CPZ\u2010exposed and control groups. We conclude that acute CPZ exposure could lead to myocardial injury in rats, in which HSPs might play a crucial role. 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