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We conducted a 19\u2010year cohort study including 1110 men and 1,03 women who lived in three cadmium\u2010non\u2010polluted areas in 1993 or 1994. Mortality risk ratios based on urinary \u03b22\u2010microglobulin (\u03b22MG) and N\u2010acetyl\u2010\u03b2\u2010glucosaminidase (NAG) concentrations were estimated for specific non\u2010cancer diseases using the Fine and Gray competing risks regression model. In men, continuous urinary NAG (+1\u2009\u03bcg\/g cre) concentrations were significantly correlated with increased mortality caused by diseases of the respiratory system (hazard ratio (HR): 1.09, 95% confidence interval (CI): 1.03\u20131.15). Urinary \u03b22MG (+100\u2009\u03bcg\/g cre) concentrations were significantly correlated with increased mortalities caused by kidney and urinary tract diseases (HR: 1.01, 95% CI: 1.00\u20131.03), renal diseases (HR: 1.01, 95% CI: 1.00\u20131.03), renal failure (HR: 1.02, 95% CI: 1.00\u20131.03), and external causes of mortality (HR: 1.01, 95% CI: 1.00\u20131.02). In women, urinary NAG (+1\u2009\u03bcg\/g cre) concentrations were significantly associated with increased mortality caused by ischemic heart diseases (HR: 1.02, 95% CI: 1.00\u20131.04) and kidney and urinary tract diseases (HR: 1.01, 95% CI: 1.00\u20131.04). Urinary \u03b22MG (+100\u2009\u03bcg\/g cre) concentrations were significantly correlated with increased mortality caused by cardiovascular diseases (HR: 1.01, 95%CI: 1.00\u20131.02), ischemic heart diseases (HR: 1.01, 95%CI: 1.00\u20131.02), and kidney and urinary tract diseases (HR: 1.02, 95% CI: 1.01\u20131.03). The present study indicates that renal tubular damage was significantly related to several non\u2010cancer disease causes of mortality in Japan's general population living in cadmium\u2010non\u2010polluted areas.<\/jats:p>","DOI":"10.1002\/jat.4518","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T19:30:43Z","timestamp":1689622243000},"page":"1849-1858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of renal tubular damage on non\u2010cancer mortality in the general Japanese population living in cadmium non\u2010polluted areas"],"prefix":"10.1002","volume":"43","author":[{"given":"Sayaka","family":"Sakuma","sequence":"first","affiliation":[{"name":"Department of Occupational and Environmental Medicine, Graduate School of Medicine Chiba University  Chiba 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