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Considerably, because of its long biological half\u2010life and very low excretion rate, Cd is inclined to accumulate and cause deleterious effects on various body organs (e.g., liver, kidney, and ovary) in humans and animals. Ovaries are the most vulnerable targets of Cd toxicity. Cd has been shown to induce oxidative stress, follicular atresia, hormonal imbalance, and impairment of oocyte growth and development. Moreover, Cd toxicity has been associated with increasing incidences of menstrual disorders, pregnancy loss, preterm births, delayed puberty, and female infertility. Therefore, it is crucial to understand how Cd poisoning impacts specific ovarian processes for the development of preventive interventions to enhance female fertility. The current review attempts to collate the recent findings on Cd\u2010induced oxidative stress, follicular apoptosis, steroid synthesis inhibition, and teratogenic toxicity, along with their possible mechanisms in the ovarian tissue of different animal species. Additionally, the review also summarizes the studies related to the use of many antioxidants, medicinal herbs, and other compounds as remedial approaches for managing Cd\u2010induced ovarian toxicity.<\/jats:p>","DOI":"10.1002\/jat.4526","type":"journal-article","created":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T17:54:00Z","timestamp":1692554040000},"page":"129-147","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Cadmium as an ovarian toxicant: A review"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2183-3058","authenticated-orcid":false,"given":"Jitender Kumar","family":"Bhardwaj","sequence":"first","affiliation":[{"name":"Reproductive Physiology Laboratory, Department of Zoology Kurukshetra University  Kurukshetra Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prerna","family":"Bikal","sequence":"additional","affiliation":[{"name":"Reproductive Physiology Laboratory, Department of Zoology Kurukshetra University  Kurukshetra Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Som Nath","family":"Sachdeva","sequence":"additional","affiliation":[{"name":"Department of Civil Engineering, National Institute of Technology Kurukshetra Kurukshetra University  Kurukshetra Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtm.2017.10.019"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/jes.2013.55"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8763"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1001967"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1515\/intox-2015-0022"},{"issue":"1","key":"e_1_2_8_7_1","first-page":"8","article-title":"Protective effect of ginger (zingiber officinal) hydro alcoholic extract on cadmium chloride induced reproductive toxicity in rats female","volume":"8","author":"AL\u2010Neamah A. 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