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For read\u2010across assessments, it is crucial to compare the target chemical with the most appropriate analog; therefore, reliable analog selection should consider physicochemical properties, bioavailability, metabolism, as well as the bioactivity of potential analogs. To complement in vitro bioactivity assays, we evaluated the suitability of three potential analogs for the UV filters, homosalate and octisalate, according to their in vitro ADME properties. We describe how technical aspects of conducting assays for these highly lipophilic chemicals were addressed and interpreted. There were several properties that were common to all five chemicals: they all had similar stability in gastrointestinal fluids (in which no hydrolysis to salicylic occurred); were not substrates of the P\u2010glycoprotein efflux transporter; were highly protein bound; and were hydrolyzed to salicylic acid (which was also a major metabolite). The main properties differentiating the chemicals were their permeability in Caco\u20102 cells, plasma stability, clearance in hepatic models, and the extent of hydrolysis to salicylic acid. Cyclohexyl salicylate, octisalate, and homosalate were identified suitable analogs for each other, whereas butyloctyl salicylate exhibited ADME properties that were markedly different, indicating it is unsuitable. Isoamyl salicylate can be a suitable analog with interpretation for octisalate. In conclusion, in vitro ADME properties of five chemicals were measured and used to pair target and potential analogs. This study demonstrates the importance of robust ADME data for the selection of analogs in a read\u2010across safety assessment.<\/jats:p>","DOI":"10.1002\/jat.4603","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T00:44:47Z","timestamp":1711586687000},"page":"1067-1083","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Use of in vitro ADME methods to identify suitable analogs of homosalate and octisalate for use in a read\u2010across safety assessment"],"prefix":"10.1002","volume":"44","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3474-6129","authenticated-orcid":false,"given":"S\u00e9bastien","family":"Gr\u00e9goire","sequence":"first","affiliation":[{"name":"L'Or\u00e9al Research &amp; Innovation  Aulnay\u2010sous Bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Mousti\u00e9","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research &amp; Innovation  Aulnay\u2010sous Bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Lereaux","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research &amp; Innovation  Aulnay\u2010sous Bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laur\u00e8ne","family":"Roussel\u2010Berlier","sequence":"additional","affiliation":[{"name":"L'Or\u00e9al Research &amp; Innovation  Aulnay\u2010sous Bois France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1045-0748","authenticated-orcid":false,"given":"Nicky","family":"Hewitt","sequence":"additional","affiliation":[{"name":"Cosmetics Europe  Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2021.105094"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.14573\/altex.1601251"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00498250400021820"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.106.011569"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2021.104931"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/2472555219848483"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0928-0987(00)00162-7"},{"key":"e_1_2_9_9_1","unstructured":"EU. 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