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However, the exact mechanisms of its reproductive toxicity remain unclear. The studies suggest that the exogenous cannabinoids may interfere with endocannabinoid system and disrupt hypothalamic\u2010pituitary\u2010ovary axis. Consequently, it impacts the female fertility by disruption of normal secretion of ovarian sex hormones and menstrual cycles. However, other studies have shown that medical marijuana is useful analgesic agent for pain management. But, given that the wide range of cannabinoids side effects are reported, it seems that caution should be taken in the recreational use of these substances. In summary, this article aimed to review the possible impacts of marijuana and its derivatives on the main female reproductive organs and embryonic growth and development.<\/jats:p>","DOI":"10.1002\/jat.4630","type":"journal-article","created":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T19:35:50Z","timestamp":1715888150000},"page":"47-60","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The marijuana, cannabinoids, and female reproductive system"],"prefix":"10.1002","volume":"45","author":[{"given":"Leila","family":"Najafi","sequence":"first","affiliation":[{"name":"Department of Anatomical Sciences Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3828-1517","authenticated-orcid":false,"given":"Zia","family":"Moasses","sequence":"additional","affiliation":[{"name":"Department of Anatomical Sciences Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soghra","family":"Bahmanpour","sequence":"additional","affiliation":[{"name":"Department of Reproductive Biology, School of Advanced Medical Sciences and Technologies Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Department of Anatomical Sciences, School of Medicine Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,5,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1983.244.2.E177"},{"key":"e_1_2_9_3_1","volume-title":"Cytotoxicity of non\u2010psychoactive cannabinoids with an emphasis on cannabidiol and ovarian cancer","author":"Ahmed L.","year":"2022"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/zeb.2012.0785"},{"key":"e_1_2_9_5_1","doi-asserted-by":"crossref","unstructured":"Alexander J. 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