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Despite the aforementioned beneficial effects of using these hormones, anabolic\u2010androgenic steroids (AAS) are also widely abused in a non\u2010therapeutic manner for muscle\u2010building and strength\u2010increasing properties that may lead to genotoxicity in different tissues. The present study aims to understand whether genotoxicity may be a suitable biomarker for AAS exposure in vivo in both experimental animal and human studies. All studies published in PubMed\/Medline, Scopus, and Web of Science electronic databases that presented data on DNA damage caused by AAS were analyzed. A total of 15 articles were included in this study, and after thoroughly reviewing the studies, a total of 8 articles were classified as Strong, 6 were classified as Moderate, and only 1 was classified as Weak, totaling 14 studies being considered either Strong or Moderate. This classification makes it possible to consider the present findings as reliable. The meta\u2010analysis data revealed a statistically significant difference in Wistar rat testis cells with AAS compared to control for tail length and % tail DNA (p\u2009&lt;\u20090.001), so that the selected articles were considered homogeneous and the I<jats:sup>2<\/jats:sup> of 0% indicated low heterogeneity. In summary, genotoxicity can be considered a suitable biomarker for monitoring AAS exposure as a result of DNA breakage and oxidative DNA damage.<\/jats:p>","DOI":"10.1002\/jat.4656","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T01:29:55Z","timestamp":1717637395000},"page":"77-88","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Is genotoxicity a suitable biomarker for monitoring anabolic\u2010androgenic steroids exposure in vivo? 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