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However, its use is greatly limited by the cardiotoxicity it induces, including doxorubicin\u2010induced cardiomyopathy (DIC). The mechanisms behind DIC are not fully understood, but its potential biological mechanisms are thought to include oxidative stress, inflammation, energy metabolism disorders, mitochondrial damage, autophagy, apoptosis, and ferroptosis. Recent studies have shown that cardiac injury induced by DOX is closely related to ferroptosis. Due to their high efficacy, availability, and low side effects, natural medicine treatments hold strong clinical potential. Currently, natural medicines have been shown to mitigate DOX\u2010induced ferroptosis and ease DIC through various functions such as antioxidation, iron ion homeostasis correction, lipid metabolism regulation, and mitochondrial function improvement. Therefore, this review summarizes the mechanisms of ferroptosis in DIC and the regulation by natural plant products, with the expectation of providing a reference for future research and development of inhibitors targeting ferroptosis in DIC.<\/jats:p><jats:p>This review explores the mechanisms of ferroptosis in doxorubicin\u2010induced cardiomyopathy (DIC) and summarizes how natural plant products can alleviate DIC by inhibiting ferroptosis through reducing oxidative stress, correcting iron ion homeostasis, regulating lipid metabolism, and improving mitochondrial function.<\/jats:p>","DOI":"10.1002\/jat.4670","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:59:27Z","timestamp":1721350767000},"page":"135-158","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Ferroptosis: Latest evidence and perspectives on plant\u2010derived natural active compounds mitigating doxorubicin\u2010induced cardiotoxicity"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2964-0170","authenticated-orcid":false,"given":"Boyu","family":"Wang","sequence":"first","affiliation":[{"name":"Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiameng","family":"Wang","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changxing","family":"Liu","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengjia","family":"Li","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianwei","family":"Meng","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Chen","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingnan","family":"Liu","sequence":"additional","affiliation":[{"name":"Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wang","family":"He","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiping","family":"Liu","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yabin","family":"Zhou","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Heilongjiang University of Chinese Medicine  Harbin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"issue":"2","key":"e_1_2_11_2_1","first-page":"164","article-title":"Review on iron and its importance for human health","volume":"19","author":"Abbaspour N.","year":"2014","journal-title":"Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.abn8017"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28030929"},{"key":"e_1_2_11_5_1","first-page":"5","article-title":"Nutritive value, levels of polyphenols and anti\u2010nutritional factors in Sri Lankan cinnamon (Cinnamomum Zeyalnicum) and Chinese cinnamon (Cinnamomum Cassia)","volume":"154","author":"Al\u2010Numair K. 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