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Contaminated soil in industrial areas poses a serious threat to human and ecosystems. Most of the studies investigated the toxicity of soil from coking plant on soil microorganisms, while the toxic effects of soil leaching liquor on aquatics are limited. In this study, the composition of soil leaching liquor from a coking plant in Taiyuan (TY) was analyzed, and the developmental toxicity on zebrafish was evaluated. The results showed that a total of 91 polycyclic aromatic hydrocarbons were detected in the leaching liquor, followed by phenols and benzene series. The leaching liquor induced developmental impairment in zebrafish larvae, including delayed incubation, deficits in locomotor behavior, vascular and cardiac dysplasia, and impaired neurodevelopment. The results of metabolomics analysis showed that TY soil leaching liquor induced significant metabolic profile disturbances in zebrafish embryos\/larvae. The developmental toxicity of the leaching liquor metabolic disorders may be associated with the leaching liquor\u2010induced abnormalities in zebrafish embryonic development. Metabolic pathways were identified by arginine and proline metabolism, phosphotransferase system, starch and sucrose metabolism, steroid biosynthesis, beta\u2010alanine metabolism, and nucleotide metabolism pathways.<\/jats:p>","DOI":"10.1002\/jat.4692","type":"journal-article","created":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T19:25:33Z","timestamp":1724268333000},"page":"1962-1975","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Toxicity of soil leaching liquor from coking plant in developmental zebrafish embryos\/larvae model"],"prefix":"10.1002","volume":"44","author":[{"given":"Guangchao","family":"Yang","sequence":"first","affiliation":[{"name":"Research and Development Center for Watershed Environmental Eco\u2010Engineering Beijing Normal University  Zhuhai 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