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Therefore, the present work aims to reveal the main targets of action, cellular processes, and molecular pathways by which cadmium causes NAFLD. As shown in the bioinformatics analysis, there were 74 main targets of action for cadmium\u2010induced NAFLD, hemopoietic cell kinase (HCK), EPH receptor A2 (EPHA2), MYC proto\u2010oncogene (MYC), lysyl oxidase (LOX), dipeptidyl peptidase 7 (DPP7), nuclear factor erythroid 2\u2010related factor 2 (NFE2L2), dual specificity phosphatase 6 (DUSP6), CD2 cytoplasmic tail binding protein 2 (CD2BP2), notch receptor 3 (NOTCH3), and phospholipase A2 group IVA (PLA2G4A) were screened as core genes. Testing these core genes in other databases, three differentially expressed genes, HCK, MYC, and DUSP6 were verified and used as targets for drug prediction in DsigDB; decitabine and retinoic acid were screened as potential therapeutic drugs for NAFLD based on the <jats:italic>p<\/jats:italic>\u2010value and the combined score. The results of molecular docking showed that the predicted drugs can bind well to the core targets. In conclusion, cadmium is associated with NAFLD; the identified cadmium\u2010toxicity targets, HCK, MYC, and DUSP6, may serve as biomarkers for the diagnosis of NAFLD and predicted drugs, decitabine and retinoic acid may have a potential role in the treatment of NAFLD.<\/jats:p>","DOI":"10.1002\/jat.4752","type":"journal-article","created":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T00:31:38Z","timestamp":1736814698000},"page":"858-865","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bioinformatic Analysis for Exploring Target Genes and Molecular Mechanisms of Cadmium\u2010Induced Nonalcoholic Fatty Liver Disease and Targeted Drug Prediction"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-7285-4914","authenticated-orcid":false,"given":"Le","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Toxicology, School of Public Health Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongjie","family":"Wang","sequence":"additional","affiliation":[{"name":"Qingdao Municipal Center for Disease Control and Prevention Qingdao Institute of Preventive Medicine  Qingdao China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayunzhu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chaofan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shidi","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiying","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology, College of Basic Medical Sciences, the Key Laboratory of Pathobiology, Ministry of Education Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Toxicology, School of Public Health Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,13]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.23806"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11695\u2010008\u20109686\u20105"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.livres.2023.07.002"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2015.01.025"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.12.019"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010023\u201040086\u20103"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2020.126601"},{"issue":"1","key":"e_1_2_10_9_1","first-page":"S5","article-title":"The Epidemiology of Nonalcoholic Fatty Liver Disease in Adults","volume":"40","author":"Clark J. 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