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This work belongs among rare whole\u2010body inhalation studies investigating the effects of TiO<jats:sub>2<\/jats:sub> NPs on mice. Unlike previous studies, the concentration of TiO<jats:sub>2<\/jats:sub> NPs in the inhalation chamber (130.8\u2009\u03bcg\/m<jats:sup>3<\/jats:sup>) was significantly lower. This 11\u2010week study on mice confirmed in\u00a0vivo the presence of TiO<jats:sub>2<\/jats:sub> NPs in lung macrophages and type II pneumocytes including their intracellular localization by using the electron microscopy and the state\u2010of\u2010the\u2010art methods detecting NPs' chemical identity\/crystal structure, such as the energy\u2010dispersed X\u2010ray spectroscopy (EDX), cathodoluminescence (CL), and detailed diffraction pattern analysis using powder nanobeam diffraction (PNBD). 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On the contrary, TiO<jats:sub>2<\/jats:sub> NPs were not confirmed in other organs (spleen, liver, and kidney); Ti was detected only in the kidney near the detection limit.<\/jats:p>","DOI":"10.1002\/jat.4759","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T18:00:27Z","timestamp":1739296827000},"page":"1004-1018","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Subchronic Inhalation of TiO<sub>2<\/sub> Nanoparticles Leads to Deposition in the Lung and Alterations in Erythrocyte Morphology in Mice"],"prefix":"10.1002","volume":"45","author":[{"given":"Pavel","family":"Kulich","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Toxicology Veterinary Research Institute  Brno Czech 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