{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T15:16:35Z","timestamp":1784646995677,"version":"3.55.0"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T00:00:00Z","timestamp":1747008000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study evaluated the impact of ulinastatin combined with high\u2010volume hemofiltration (HVHF) on inflammation and the development of multiple organ dysfunction syndrome (MODS) in severe sepsis. One hundred patients with severe sepsis were recruited and allocated into two groups based on treatment methods (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200950 patients). The control group underwent HVHF, while the observation group received ulinastatin\u2010assisted HVHF. Comparisons of general data were made in treatment efficacy (APACHE II score), MODS score, and SOFA score. Inflammatory markers and organ function indicators were also measured before and after treatment. The incidence of disseminated intravascular coagulation (DIC), MODS, and mortality rates at 28\u2009days were also analyzed. The observation group showed significantly reduced APACHE II, MODS, and SOFA scores, along with lower levels of IL\u20106, IL\u201010, TNF\u2010\u03b1, ALT, and Scr (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Additionally, the observation group had lower incidences of DIC, MODS, and mortality (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Furthermore, elevated CD4+ and CD4+\/CD8+ ratios while reduced CD8+ levels were noted in the observation group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). We demonstrate that ulinastatin combined with HVHF effectively reduces inflammatory levels in patients with severe sepsis, improves organ function, lowers the incidence of MODS and mortality, and enhances immune function.\n                  <\/jats:p>","DOI":"10.1002\/jat.4804","type":"journal-article","created":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:23:28Z","timestamp":1747095808000},"page":"1839-1843","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Effect of Ulinastatin Combined With High\u2010Volume Hemofiltration on Inflammatory Response and MODS Incidence in Severe Sepsis"],"prefix":"10.1002","volume":"45","author":[{"given":"Xuhong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit The Affiliated Cancer Hospital of Nanjing Medical University (Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research)  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuliang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit The Affiliated Cancer Hospital of Nanjing Medical University (Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research)  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit The Affiliated Cancer Hospital of Nanjing Medical University (Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research)  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit The Affiliated Cancer Hospital of Nanjing Medical University (Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research)  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2684-3641","authenticated-orcid":false,"given":"Nan","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit The Affiliated Cancer Hospital of Nanjing Medical University (Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research)  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2021.103776"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/nicc.12401"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000520519"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-15-2385-4_11"},{"issue":"8","key":"e_1_2_7_6_1","first-page":"4326","article-title":"Ulinastatin Attenuates Monocyte\u2010Endothelial Adhesion via Inhibiting ROS Transfer Between the Neighboring Vascular Endothelial Cells Mediated by Cx43","volume":"12","author":"Ding H.","year":"2020","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.21037\/apm.2020.04.19"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.0071"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/aor.14016"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2022.108908"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.977094"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-022-00422-y"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26930"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-69202-z"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.21037\/tp.2020.03.13"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106643"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000027151"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fsurg.2022.899753"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.10.012"},{"issue":"7","key":"e_1_2_7_20_1","first-page":"421","article-title":"Study the Effects of High\u2010Volume Hemofiltration and Fluid Resuscitation on Removing Blood Lactic Acid and Pro\u2010Inflammatory Cytokines in Patients With Refractory Septic Shock","volume":"21","author":"Wang C. T.","year":"2009","journal-title":"Zhongguo wei Zhong Bing ji jiu yi xue= Chinese Critical Care Medicine= Zhongguo Weizhongbing Jijiuyixue"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v9.i9.2096"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S491193"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S303577"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12890-024-03083-w"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm.2020.03.48"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1434688"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.4804","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T16:23:24Z","timestamp":1767025404000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.4804"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,12]]},"references-count":25,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/jat.4804"],"URL":"https:\/\/doi.org\/10.1002\/jat.4804","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5,12]]},"assertion":[{"value":"2025-03-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-25","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}