{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T16:28:48Z","timestamp":1767025728960,"version":"3.48.0"},"reference-count":50,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004491","name":"Balikesir \u00dcniversitesi","doi-asserted-by":"publisher","award":["2023\/050"],"award-info":[{"award-number":["2023\/050"]}],"id":[{"id":"10.13039\/501100004491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Diabetes mellitus (DM) is one of the five leading causes of death worldwide. Finasteride is an inhibitor of type 2 5\u2010alpha reductase enzyme. In this study, we aimed to investigate the effects of finasteride on apoptosis, oxidative stress, antioxidants, and cytokines in the liver, kidney, and testis in an experimental diabetes model in rats. Thirty\u2010two male rats were randomly divided into four equal groups as follows: control, finasteride (30\u2009mg\/kg 14\u2009days by gastric gavage), diabetes, and diabetes+finasteride. Malondialdehyde (MDA), superoxide dismutase (SOD), and total antioxidant status (TAS) levels in liver, kidney, and testis tissues, and nitric oxide (NO), interleukin 6 (IL\u20106), and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) levels in blood samples were examined. In addition, tissue sections were evaluated immunohistochemically (B\u2010cell lymphoma 2 (Bcl\u20102), Bcl\u20102 associated X protein (Bax)) and histopathologically. Induction of diabetes with streptozotocin resulted in an increase MDA, NO, IL\u20106, TNF\u2010\u03b1 levels whereas TAS and SOD decreased compared to the control group. Diabetes+Finasteride group was compared with the diabetes group decrease in MDA, NO, IL\u20106, TNF\u2010\u03b1 levels, and increase in TAS and SOD levels were observed. Finasteride suppressed apoptosis through the down regulation of Bax and the induction of the expression of Bcl\u20102 in the liver and kidney. Finasteride administration ameliorated some histopathological changes and decreased oxidative stress, apoptosis, and inflammation while increasing the antioxidant defense system in the STZ\u2010induced diabetes group. In conclusion, finasteride might show a protective effect by suppressing oxidative stress and apoptosis and downregulation of proinflammatory cytokines in diabetic rats with its antioxidant and antiapoptotic effects. Human trials are needed before clinical application.<\/jats:p>","DOI":"10.1002\/jat.4823","type":"journal-article","created":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T18:29:18Z","timestamp":1748802558000},"page":"2042-2054","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Effects of Finasteride on Apoptosis, Antioxidants, and Cytokines in Experimental Diabetes Rats"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6595-7821","authenticated-orcid":false,"given":"Dilek","family":"Aksit","sequence":"first","affiliation":[{"name":"Department of Forensic Sciences, Faculty of Engineering and Natural Sciences K\u00fctahya Health Sciences University  K\u00fctahya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9110-8364","authenticated-orcid":false,"given":"Eren","family":"Altun","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Health Sciences, Bagcilar Training and Research Hospital  Istanbul Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1769-2512","authenticated-orcid":false,"given":"Murat","family":"Celebi","sequence":"additional","affiliation":[{"name":"Department of Veterinary, Savastepe Vocational School University of Balikesir  Balikesir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6253-7346","authenticated-orcid":false,"given":"Cagla","family":"Celebi","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine University of Balikesir  Balikesir Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5430-9917","authenticated-orcid":false,"given":"Hasan","family":"Aksit","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Faculty of Engineering and Natural Sciences K\u00fctahya Health Sciences University  K\u00fctahya Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2014.937504"},{"key":"e_1_2_9_3_1","first-page":"927","article-title":"Oxidative Stress Induced by Diabetes Activates Apoptosis in Rat Brain","volume":"12","author":"Aksit H.","year":"2013","journal-title":"Journal of Animal and Veterinary Advances"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745\u20107262.2006.00177.x"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.22037\/ijpr.2012.1217"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759091419899782"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939\u20104640.1986.tb00862.x"},{"key":"e_1_2_9_8_1","first-page":"82","article-title":"Antioxidative and a Cell Regeneration Effect of capparis aphylla Stem Extract in Streptozotocin Induced Diabetic Rat","volume":"3","author":"Dangi K. 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