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Noncoding RNAs may hold the key to understanding the complex pathways involved in cadmium\u2010induced carcinogenesis. This study reveals a novel regulatory network involving circ_000877, lnc237177, and miR\u20103192\u20105p, which targets cyclin\u2010D1(CCND1) and matrix metalloproteinase 2 (MMP\u20102), thereby promoting the Cd\u2010induced malignant transformation of human bronchial epithelial (16HBE) cells. Utilizing an established 16HBE malignant transformation model induced by Cd exposure, RNA sequencing and quantitative real\u2010time polymerase chain reaction (qRT\u2010PCR) analyses indicated that both circ_000877 and lnc237177 were significantly upregulated. Functional assays further confirmed the roles of these molecules in facilitating malignant transformation. Mechanistically, circ_000877 and lnc237177 collaboratively targeted miR\u20103192\u20105p, thereby modulating both mRNA and protein expression levels of cyclin\u2010D1 and MMP\u20102. Collectively, this study offers novel perspectives into the mechanism through which circRNA and lncRNA jointly regulate miRNA in a crosstalk network during Cd\u2010induced malignant transformation, thereby enhancing our understanding of cadmium's toxicological impact.<\/jats:p>","DOI":"10.1002\/jat.4838","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:09:51Z","timestamp":1750205391000},"page":"2174-2183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["A Novel Regulatory Network of Noncoding RNAs in the Cadmium\u2010Induced Malignant Transformation of Human Bronchial Epithelial Cells"],"prefix":"10.1002","volume":"45","author":[{"given":"Yueqing","family":"Shao","sequence":"first","affiliation":[{"name":"School of Public Health Baotou Medical College  Baotou 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