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Recent investigations have increasingly focused on its influence on testicular function and male fertility. This research aims to assess the protective effects of ATV against testicular injury induced by lipopolysaccharide (LPS). Mice were subjected to daily administration of LPS (250\u2009\u03bcg\/kg; i.p.) for a duration of 7\u2009days. Concurrently, ATV (25 and 50\u2009mg\/kg; orally) was administered daily alongside LPS treatment, while a control group received normal saline. ATV was found to elevate testosterone and 5\u03b1\u2010dihydrotestosterone (DHT) levels, reduce oxidative stress by lowering malondialdehyde (MDA) levels and increasing glutathione (GSH) and Nrf2 levels. Additionally, it mitigated inflammation by downregulating tumor necrosis factor\u2010alpha (TNF\u2010\u03b1), nuclear factor\u2010kappa B (NF\u2010\u03baB), MAPK\/ERK, and the NLRP3 inflammasome. Moreover, ATV upregulates peroxisome proliferator\u2010activated receptor gamma (PPAR\u03b3), which is essential for cellular metabolism and immune regulation. The findings indicate that ATV possesses significant protective effects against LPS\u2010induced testicular damage by alleviating oxidative stress, suppressing inflammatory responses, and fostering testicular homeostasis. Its capacity to enhance spermatogenesis underscores its potential as a promising therapeutic strategy for addressing male infertility.<\/jats:p>","DOI":"10.1002\/jat.4851","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T01:39:09Z","timestamp":1751593149000},"page":"2321-2329","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Protective Effects of Atorvastatin on LPS\u2010Induced Testicular Damage: Modulation of Spermatogenesis via PPAR\u2010\u03b3, NF\u2010\u03baB, and NLRP3 Pathways"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2948-5449","authenticated-orcid":false,"given":"Rania","family":"Elgohary","sequence":"first","affiliation":[{"name":"Narcotics, Ergogenics and Poisons Department, Medical Research and Clinical Studies Institute National Research Centre (NRC)  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amany\u00a0A.","family":"El\u2010Fadaly","sequence":"additional","affiliation":[{"name":"Pharmacology Department, Medical Research and Clinical Studies Institute National Research Centre (NRC)  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9870-5583","authenticated-orcid":false,"given":"Abeer","family":"Salama","sequence":"additional","affiliation":[{"name":"Pharmacology Department, Medical Research and Clinical Studies Institute National Research Centre (NRC)  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2024.142852"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113799"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.1.1.6843"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtemb.2023.127315"},{"issue":"5","key":"e_1_2_11_6_1","first-page":"IE01","article-title":"The Impact of Oxidative Stress on Testicular Function and the Role of Antioxidants in Improving It: A Review","volume":"11","author":"Asadi N.","year":"2017","journal-title":"Journal of Clinical and Diagnostic Research"},{"issue":"3","key":"e_1_2_11_7_1","first-page":"123","article-title":"Impact of Inflammation on Male Reproductive Tract","volume":"16","author":"Azenabor A.","year":"2015","journal-title":"Journal of Reproduction & Infertility"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2018.02.010"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-023-01401-x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mca.0000131573.31966.34"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms221810043"},{"key":"e_1_2_11_12_1","first-page":"1","article-title":"Ginger and Atorvastatin Protect Against Diazinon\u2010Induced Testicular Damage in Rats Through Regulation of Oxidative Stress, Inflammation, and Apoptosis","author":"Elshafae R.","year":"2025","journal-title":"Egyptian Journal of Veterinary Science"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612826666201207104340"},{"issue":"3","key":"e_1_2_11_14_1","first-page":"373","article-title":"Regulation of Steroidogenic Function of Mouse Leydig Cells: G\u2010Coupled Membrane Estrogen Receptor and Peroxisome Proliferator\u2010Activated Receptor Partnership","volume":"69","author":"G\u00f3rowska\u2010W\u00f3jtowicz E.","year":"2018","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-89340-8_15"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-5362.236837"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.03.041"},{"key":"e_1_2_11_18_1","first-page":"805","article-title":"The Immunophysiology of Male Reproduction","volume":"1","author":"Hedger M. 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