{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:45:40Z","timestamp":1786977940793,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,7,18]],"date-time":"2025-07-18T00:00:00Z","timestamp":1752796800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004491","name":"Balikesir \u00dcniversitesi","doi-asserted-by":"publisher","award":["2021\/127"],"award-info":[{"award-number":["2021\/127"]}],"id":[{"id":"10.13039\/501100004491","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Nephrotoxicity is one of the most important side effects of aminoglycosides, especially gentamicin. This study investigated the potential protective effect of vitamin D against gentamicin\u2010induced kidney damage in rats. Forty\u2010two male Wistar Albino rats were randomly divided into six groups. The control group received saline. The gentamicin group was treated with intraperitoneal gentamicin (100\u2009mg\/kg) for 7\u2009days. Vitamin D (1000\u2009IU\/kg) was given to the D1 group for 1\u2009week and to the D2 group for 2\u2009weeks by oral gavage. The simultaneous treatment group received both gentamicin and vitamin D in combination for 1\u2009week. In the pretreatment group, vitamin D was administered during the first week, and then gentamicin and vitamin D were administered together for the second week. At the end of the drug administration, all rats were sacrificed. Blood and kidney samples of rats were analyzed using biochemical methods. Rat kidneys were examined using electron microscopes. Both vitamin D treatments decreased gentamicin\u2010induced elevations in MDA, TNF\u2010\u03b1, and IL\u20106. In addition, in the vitamin D pretreatment group, gentamicin\u2010induced rises in creatinine and urea, and decreases in SOD were also lessened. Ultrastructural indicators were improved, especially with vitamin D pretreatment. The anti\u2010inflammatory and antioxidant properties of vitamin D protect against gentamicin\u2010induced nephrotoxicity. The protective effect was considerably stronger if vitamin D was administered as a pretreatment. In conclusion, vitamin D supplementation before gentamicin treatment in the clinic may be an effective option to prevent the development of nephrotoxicity.<\/jats:p>","DOI":"10.1002\/jat.4862","type":"journal-article","created":{"date-parts":[[2025,7,19]],"date-time":"2025-07-19T06:40:03Z","timestamp":1752907203000},"page":"2613-2623","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Vitamin D Protects Against Gentamicin\u2010Induced Kidney Damage in Rats Through Its Antioxidant and Anti\u2010Inflammatory Effects"],"prefix":"10.1002","volume":"45","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4827-804X","authenticated-orcid":false,"given":"Elif","family":"Aksoz","sequence":"first","affiliation":[{"name":"Department of Medical Pharmacology, Faculty of Medicine Balikesir University  Balikesir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8433-1194","authenticated-orcid":false,"given":"Fazilet\u00a0Sen","family":"Metin","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology, Faculty of Medicine Balikesir University  Balikesir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7985-1910","authenticated-orcid":false,"given":"Nurullah","family":"Guclu","sequence":"additional","affiliation":[{"name":"Department of Medical Pharmacology, Faculty of Medicine Balikesir University  Balikesir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1769-2512","authenticated-orcid":false,"given":"Murat","family":"Celebi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine, Savastepe Vocational School Balikesir University  Balikesir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8133-8665","authenticated-orcid":false,"given":"Sinem\u00a0Kantarcioglu","family":"Coskun","sequence":"additional","affiliation":[{"name":"T.C. 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