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Humans are exposed to Cd via the oral route throughout their lifetime, which can adversely affect their health. The present study was done to delineate the mechanism of acute toxicity of cadmium chloride (CdCl\n                    <jats:sub>2<\/jats:sub>\n                    ) on rat intestine. Adult male Wistar rats were given a single oral dose of CdCl\n                    <jats:sub>2<\/jats:sub>\n                    at 30, 60, 90, and 120\u2009mg\/kg body weight. The administration of CdCl\n                    <jats:sub>2<\/jats:sub>\n                    impaired the enzymatic and non\u2010enzymatic antioxidant defense systems, which lowered the total antioxidant capacity of intestinal cells. The oxidation of lipids, proteins, and thiol groups was significantly increased. The activities of enzymes of the brush border membrane and glucose metabolism were also altered. DNA strand scission and DNA\u2010protein cross\u2010linking were enhanced in CdCl\n                    <jats:sub>2<\/jats:sub>\n                    \u2010treated rats. Histopathologic images supported the biochemical findings and showed detrimental changes in the intestine of CdCl\n                    <jats:sub>2<\/jats:sub>\n                    \u2010treated rats. All effects were seen in a CdCl\n                    <jats:sub>2<\/jats:sub>\n                    dose\u2010dependent manner. The results of this study strongly suggest that the toxic effects of CdCl\n                    <jats:sub>2<\/jats:sub>\n                    in rat intestine are due to the induction of oxidative stress that lowers the antioxidant defense system, leading to tissue damage.\n                  <\/jats:p>","DOI":"10.1002\/jat.4879","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T07:04:34Z","timestamp":1754031874000},"page":"160-171","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Oral Administration of Cadmium Chloride Induces Oxidative Stress, DNA Damage and Histopathological Changes in Rat Intestine: A Dose\u2010Dependent Study"],"prefix":"10.1002","volume":"46","author":[{"given":"Zarmin","family":"Iqbal","sequence":"first","affiliation":[{"name":"Department of Biochemistry, Faculty of Life Sciences Aligarh Muslim University  Aligarh U.P. 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