{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T18:49:04Z","timestamp":1780080544926,"version":"3.54.0"},"reference-count":40,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T00:00:00Z","timestamp":1756166400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFD1300802\u20104"],"award-info":[{"award-number":["2023YFD1300802\u20104"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    T\u20102 mycotoxin is a highly toxic type A trichothecene mycotoxin that widely contaminates livestock feed, posing a serious threat to animal and human health. Long\u2010term exposure can lead to immunosuppression, growth retardation, and liver damage, causing significant economic losses to the livestock industry. Offspring are particularly susceptible to maternal dietary influences during pregnancy and lactation. This research aimed to evaluate the impact of T\u20102 mycotoxin exposure on both dams and their pups. Thirty pregnant mice were randomly allocated into three groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200910). From gestational day 14 to lactational day 21, the dams received gavage doses of T\u20102 mycotoxin at concentrations of 0, 0.005, and 0.05\u2009mg\/kg\/day. Randomly selected one male pup and one female pup from each dam were sacrificed on LD 1, 7, and 21; dams were dosed until the day they were sacrificed. T\u20102 mycotoxin decreased the relative body\/organ weights of the dams and offspring (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Moreover, T\u20102 mycotoxin\u2010induced oxidative stress in dams and offspring increased the malondialdehyde content, which led to reduced activities of antioxidant enzymes, including catalase, superoxide dismutase, and glutathione peroxidase, and total antioxidant capacity in the serum and liver (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). T\u20102 mycotoxin induced histomorphological changes in the liver and early involution of the mammary gland acini in dams. The concentrations of liver\u2010metabolizing enzymes such as glutamic oxaloacetic transaminase and glutamic pyruvic transaminase increased in offspring (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). The serum insulin\u2010like growth factor\u20101 level in offspring was decreased, which may impair the development of vital organs such as the liver, kidneys, and spleen in offspring. Consequently, the body weight and length of the offspring of exposed dams decreased. This study revealed that T\u20102 mycotoxin exposure during late gestation and entire lactation harms dams, damages mammary gland acini, alters liver biochemistry, induces oxidative stress, and delays offspring growth while also impairing maternal weight gain during lactation.\n                  <\/jats:p>","DOI":"10.1002\/jat.4911","type":"journal-article","created":{"date-parts":[[2025,8,27]],"date-time":"2025-08-27T01:38:26Z","timestamp":1756258706000},"page":"537-550","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Maternal T\u20102 Mycotoxin Exposure Impairs Liver Function and Growth in Both Dams and Offspring in Mice"],"prefix":"10.1002","volume":"46","author":[{"given":"Kai","family":"Wang","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aneela","family":"Perveen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University  Nanjing Jiangsu China"},{"name":"Livestock and Fisheries Department Government of Sindh  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiakun","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niaz\u00a0Ali","family":"Kaka","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University  Nanjing Jiangsu China"},{"name":"Livestock and Fisheries Department Government of Sindh  Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yansen","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunmei","family":"Li","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.15422"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2024.117169"},{"key":"e_1_2_9_4_1","first-page":"281","article-title":"Significance of Apoptosis and Its Relationship to Antioxidants After Ochratoxin A Administration in Mice","volume":"3","author":"Atroshi F.","year":"2000","journal-title":"Journal of Pharmacy & Pharmaceutical Sciences"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2005.07.011"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.11.070191.002141"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf00071a027"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010019\u201002577\u20105"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2013.07.017"},{"key":"e_1_2_9_10_1","first-page":"225","article-title":"T2\u2010Toxin Hepatotoxicity in the In\u00a0Situ Rat Liver Model","volume":"3","author":"Daraei B.","year":"2004","journal-title":"Iranian Journal of Pharmaceutical Research"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms9112146"},{"key":"e_1_2_9_12_1","unstructured":"European C.2000. \u201cOpinion of the Scientific Committee on Food on Fusarium Toxins.\u201d"},{"key":"e_1_2_9_13_1","unstructured":"Evaluation of Certain Mycotoxins in Food.2002. \u201cFifty\u2010Sixth Report of the Joint FAO\/WHO Expert Committee on Food Additives.\u201d World Health Organization Technical Report Series. 906 1\u201362."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0101-20612004000400030"},{"key":"e_1_2_9_15_1","volume-title":"Mycotoxins in Feed Grains and Ingredients","author":"Herrman T. J.","year":"2002"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.36233\/0507\u20104088\u201029"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0940\u20102993(01)80004\u2010x"},{"key":"e_1_2_9_18_1","unstructured":"Joint F. W. E. C. andH.O.World.2001. \u201cSafety Evaluation of Certain Mycotoxins in Food.\u201d Food & Agriculture Org. 9251046646."},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0021\u20109673(98)00720\u20101"},{"key":"e_1_2_9_20_1","first-page":"64","article-title":"Transplacental Transfer of T2\u2010Toxin: Pathological Effect","volume":"10","author":"Lafarge\u2010Frayssinet C.","year":"1990","journal-title":"Journal of Environmental Pathology, Toxicology and Oncology"},{"key":"e_1_2_9_21_1","first-page":"64","article-title":"Transplacental Transfer of T2\u2010Toxin: Pathological Effect","volume":"10","author":"Lafarge\u2010Frayssinet C.","year":"1990","journal-title":"Journal of Environmental Pathology, Toxicology and Oncology: Official Organ of the International Society for Environmental Toxicology and Cancer"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161207780249146"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2021.101245"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2022.113044"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041\u20100101(94)90398\u20100"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1080\/01926230701595292"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104615\u20100629\u20104_3"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0041\u20100101(88)90139\u20100"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.1551"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439\u20100442.1994.tb00070.x"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2005.02.005"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(71)90267\u20104"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2023.121784"},{"key":"e_1_2_9_34_1","first-page":"743","article-title":"Effect of Prenatal Administration of T\u20102 Mycotoxin to Mice","volume":"10","author":"Stanford G. K.","year":"1975","journal-title":"Research Communications in Chemical Pathology and Pharmacology"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2003.11.006"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2017.01083"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0278\u20106915(01)00122\u20103"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.01.008"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1039\/c4mb00622d"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2009.04.002"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010014\u20101280\u20100"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.4911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T04:10:00Z","timestamp":1768191000000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.4911"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,26]]},"references-count":40,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/jat.4911"],"URL":"https:\/\/doi.org\/10.1002\/jat.4911","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,26]]},"assertion":[{"value":"2025-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}