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These plants are widely used in both human and animal nutrition, as well as in phytotherapeutic applications. While the toxic effects of L\u2010mimosine have been extensively studied in ruminants, its impact on monogastric species remains unexplored. Given the widespread use of these plants and the limited knowledge regarding L\u2010mimosine toxicity in monogastric animals, this study aimed to investigate its toxicological effects in non\u2010rodent monogastric species by assessing its subacute toxicity. To achieve this, L\u2010mimosine was extracted from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>L. leucocephala<\/jats:italic>\n                    <\/jats:styled-content>\n                    seeds and administered orally, incorporated into the feed, at doses of 25, 40, and 60\u2009mg\/kg for 28\u2009days in male rabbits. Although no clinical, biochemical, hormonal, or macroscopic alterations were observed, histopathological analyses revealed dose\u2010dependent lesions in the liver, kidneys, thyroid, and spleen. These findings suggest that rabbits may be particularly susceptible to the toxic effects of L\u2010mimosine.\n                  <\/jats:p>","DOI":"10.1002\/jat.4913","type":"journal-article","created":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T11:47:22Z","timestamp":1756986442000},"page":"639-651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Systemic Toxicity of L\u2010Mimosine in Rabbits: A Non\u2010Rodent Model for Safety Assessment"],"prefix":"10.1002","volume":"46","author":[{"given":"S.\u00a0M.","family":"Ferreira","sequence":"first","affiliation":[{"name":"Research Centre for Veterinary Toxicology (CEPTOX) \u2013 Department of Pathology, School of Veterinary Medicine and Animal Sciences University of S\u00e3o Paulo  Pirassununga SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Zapparoli","sequence":"additional","affiliation":[{"name":"Research Swine Center (NPS) \u2013 Department of Animal Reproduction, School of Veterinary Medicine and Animal Sciences University of S\u00e3o Paulo  Pirassununga SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.\u00a0S.","family":"Mussi","sequence":"additional","affiliation":[{"name":"Research Centre for Veterinary Toxicology (CEPTOX) \u2013 Department of Pathology, School of Veterinary Medicine and Animal Sciences University of S\u00e3o Paulo  Pirassununga SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.\u00a0C.","family":"Maiorka","sequence":"additional","affiliation":[{"name":"Research Centre for Veterinary Toxicology (CEPTOX) \u2013 Department of Pathology, School of Veterinary Medicine and Animal Sciences University of S\u00e3o Paulo  Pirassununga SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0148-4372","authenticated-orcid":false,"given":"A.\u00a0F.\u00a0C.","family":"Andrade","sequence":"additional","affiliation":[{"name":"Research Swine Center (NPS) \u2013 Department of Animal Reproduction, School of Veterinary Medicine and Animal Sciences University of S\u00e3o Paulo  Pirassununga SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2766-8751","authenticated-orcid":false,"given":"S.\u00a0L.","family":"G\u00f3rniak","sequence":"additional","affiliation":[{"name":"Research Centre for Veterinary Toxicology (CEPTOX) \u2013 Department of Pathology, School of Veterinary Medicine and Animal Sciences University of S\u00e3o Paulo  Pirassununga SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7297-0522","authenticated-orcid":false,"given":"A.\u00a0T.","family":"Gotardo","sequence":"additional","affiliation":[{"name":"Research Centre for Veterinary Toxicology (CEPTOX) \u2013 Department of Pathology, School of Veterinary Medicine and Animal Sciences University of S\u00e3o Paulo  Pirassununga SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/10889868.2020.1837724"},{"key":"e_1_2_10_3_1","first-page":"118","article-title":"Effects of Dietary Inclusion of Differently Processed Leucaena leucocephala Leaf Meal on Carcass Characteristics of Rabbits (Oryctolagus cunniculus)","volume":"4","author":"Adekojo S. 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