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The present study highlights the new biotechnological potential of cMoL lectin as an antifungal agent against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Cryptococcus neoformans<\/jats:italic>\n                    <\/jats:styled-content>\n                    B3501 and H99 and\n                    <jats:italic>Cryptococcus gattii<\/jats:italic>\n                    R265 strains. Acute toxicity and genotoxicity were assessed to provide information on security utilization. The antifungal activity was evaluated using the broth microdilution test, flow cytometry, antibiofilm activity, and synergistic effects with fluconazole. Acute toxicity was determined by administering a single dose of cMoL (200\u2009mg\/kg) to female Swiss albino mice and examining the following parameters: water and feed consumption, weight variation, blood hematological and biochemical parameters, serum cytokine levels, and histopathological analyses. Genotoxicity was assessed using comet assay and micronucleus test. cMoL inhibited the growth of all tested isolates, with a minimal inhibitory concentration of 7.5\u2009\u03bcg\/mL. Flow cytometry data showed that cMoL (7.5\u2009\u03bcg\/mL) significantly decreased cell viability by promoting necrosis. cMoL was not found to be an antibiofilm agent against\n                    <jats:italic>Cryptococcus<\/jats:italic>\n                    species; however, it acted synergistically with fluconazole against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C.\u2009neoformans<\/jats:italic>\n                    <\/jats:styled-content>\n                    H99. cMoL (200\u2009mg\/kg) did not cause animal death or toxicity. No hematological, biochemical, histopathological, or genotoxic effects were observed. These results encourage the exploration of cMoL as a natural and safe antifungal agent against\n                    <jats:italic>Cryptococcus<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1002\/jat.4922","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T06:19:58Z","timestamp":1757485198000},"page":"682-696","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Acute Toxicity and Genotoxicity of cMoL, a Lectin From\n                    <scp>\n                      <i>Moringa oleifera<\/i>\n                    <\/scp>\n                    Seeds With Antifungal Activity Against\n                    <scp>\n                      <i>Cryptococcus<\/i>\n                    <\/scp>\n                    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