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Upon exposure, it accumulates in various organs and disrupts normal physiological functions. In the liver, it induces oxidative stress by generating reactive oxygen species and impairing antioxidant defenses, leading to hepatotoxicity. Plant\u2010derived antioxidants have shown considerable efficacy in mitigating such toxic effects. Therefore, this study evaluates the hepatoprotective potential of morin, a bioactive flavonoid, against lead\u2010induced oxidative damage and structural alterations in male Wistar rats. Animals were allocated equally into four experimental groups: control, morin\u2010treated (50\u2009mg\/kg b.wt), lead\u2010exposed (30\u2009mg\/kg b.wt), and lead\u2009+\u2009morin co\u2010treated group, which received respective doses intragastrically for 28\u2009days. Results showed that morin significantly attenuated lead\u2010induced hepatotoxicity as indicated by reduced lipid peroxidation and protein oxidation in biochemical assays. The FTIR analysis further confirmed oxidative modifications in lipid and protein structure, implying disruption of their molecular integrity due to lead exposure. Further, morin treatment considerably improved the activities of acetylcholinesterase, superoxide dismutase, and catalase, along with increased glutathione content in lead\u2010exposed rats. The molecular docking analysis also revealed a strong binding affinity (\u22126.55 and \u22128.97\u2009kcal\/mol) of morin with superoxide dismutase and catalase, supporting its role in modulating antioxidant defense mechanisms. Morin also prevented lead\u2010induced hepatic deformities, including hydropic degeneration, portal vein congestion, and extensive collagen fiber deposition, as demonstrated by the histological and electron microscopy examinations. Conclusively, this subchronic study highlights morin's therapeutic potential and antioxidative efficacy in the liver tissue of rats subjected to lead exposure.<\/jats:p>","DOI":"10.1002\/jat.4946","type":"journal-article","created":{"date-parts":[[2025,10,2]],"date-time":"2025-10-02T02:22:15Z","timestamp":1759371735000},"page":"1018-1036","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hepatoprotective Effect of Morin Against Lead\u2010Induced Oxidative Stress and Structural Alterations in Male Wistar Rats: An In\u00a0Vivo and In Silico Approach"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-0559-8749","authenticated-orcid":false,"given":"Reena","family":"Sheoran","sequence":"first","affiliation":[{"name":"Department of Zoology Maharshi Dayanand University  Rohtak Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7726-7285","authenticated-orcid":false,"given":"Shakti","family":"Bhardwaj","sequence":"additional","affiliation":[{"name":"Department of Zoology Maharshi Dayanand University  Rohtak Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7456-5405","authenticated-orcid":false,"given":"Annu","family":"Phogat","sequence":"additional","affiliation":[{"name":"Department of Zoology Maharshi Dayanand University  Rohtak Haryana India"},{"name":"Department of Zoology RPS Degree College  Mahendergarh Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8425-959X","authenticated-orcid":false,"given":"Arun","family":"Hasanpuri","sequence":"additional","affiliation":[{"name":"Department of Zoology Maharshi Dayanand University  Rohtak Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8909-9542","authenticated-orcid":false,"given":"Vinay","family":"Malik","sequence":"additional","affiliation":[{"name":"Department of Zoology Maharshi Dayanand University  Rohtak Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010021\u201014722\u20108"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010020\u201007718\u20103"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011\u2010022\u201003325\u20100"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210\u2010022\u201002351\u2010y"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.24255"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2007.03.015"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2019.12.035"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033\u2010020\u201005346\u20101"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11011\u2010024\u201001410\u2010y"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1515\/intox\u20102015\u20100022"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9010010"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010022\u201023540\u20105"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfbc.13241"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph16020274"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10661\u2010016\u20105560\u20104"},{"issue":"2","key":"e_1_2_10_17_1","first-page":"399","article-title":"Morin and Hesperidin Ameliorate Cisplatin\u2010Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study","volume":"31","author":"Apayd\u0131n F. 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