{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T20:15:09Z","timestamp":1783628109054,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T00:00:00Z","timestamp":1761436800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T00:00:00Z","timestamp":1761436800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    To analyze and compare the effects of zoledronic acid (Aclasta) and denosumab (Prolia) treatment on sex hormones, bone mineral density (BMD), 25\u2010hydroxyvitamin D (25(OH)D), procollagen type 1\u2009N\u2010terminal propeptide (P1NP), beta\u2010CrossLaps (\u03b2\u2010CTX), and adverse effects. Eighty postmenopausal women with osteoporosis were consecutively enrolled and then randomly assigned to two groups: 40 received zoledronic acid plus standard care (control group) and 40 received denosumab plus standard care (research group). Outcomes included sex hormone levels, BMD (lumbar spine, hip, and femoral neck), bone metabolism markers (25(OH)D, P1NP, and \u03b2\u2010CTX), and adverse reactions, assessed over 1\u2009year. No significant differences in luteinizing hormone, follicle\u2010stimulating hormone, or estradiol levels were observed between the groups before and after treatment (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05). The baseline BMD and bone marker levels were similar between the groups (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05). After 6\u2009months and 1\u2009year, the denosumab group showed significantly higher BMD and 25(OH)D levels and lower P1NP and \u03b2\u2010CTX levels than the zoledronic acid group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Adverse reactions were less frequent with denosumab (2.5%) than with zoledronic acid (27.5%) (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). Zoledronic acid and denosumab have comparable effects on sex hormone regulation. Denosumab has demonstrated superior improvements in BMD, bone metabolism, and safety profiles.\n                  <\/jats:p>","DOI":"10.1002\/jat.4967","type":"journal-article","created":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:51:12Z","timestamp":1761519072000},"page":"1530-1539","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy and Safety of Denosumab and Zoledronic Acid in the Treatment of Postmenopausal Osteoporosis\u2014A Comparative Study of Bone Metabolism, Bone Density, and Sex Hormone Levels"],"prefix":"10.1002","volume":"46","author":[{"given":"Huiling","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Foresea Life Insurance Guangxi Hospital  Nanning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinyan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Pu'er People's Hospital  Pu'er China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6996-2166","authenticated-orcid":false,"given":"Xufeng","family":"Fan","sequence":"additional","affiliation":[{"name":"College of Basic Medical Sciences Hubei College of Chinese Medicine  Jingzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2022.101775"},{"issue":"6","key":"e_1_2_12_3_1","first-page":"733","article-title":"(The China Guideline for the Diagnosis Criteria of Osteoporosis With Quantitative Computed Tomograph Working Group). The China Guideline for the Diagnosis Criteria of Osteoporosis With Quantitative Computed Tomography (QCT)","volume":"25","author":"Cheng X. G.","year":"2019","journal-title":"Chinese Journal of Osteoporosis"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmab162"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/jbmr\/zjae055"},{"key":"e_1_2_12_6_1","first-page":"320","volume-title":"Obstetrics and Gynecology","author":"Feng Youji S. 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