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This study evaluates the concentration and the exposure\u2010mediated harmful effects of CBZ on important food fish\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Channa striata<\/jats:italic>\n                    <\/jats:styled-content>\n                    . The lethal concentration (LC\n                    <jats:sub>50<\/jats:sub>\n                    ) value of pesticide CBZ was calculated as 0.330\u2009mg\/L for 96\u2009h of exposure. A total of 45\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. striata<\/jats:italic>\n                    <\/jats:styled-content>\n                    were divided into three groups. The first group was unexposed; the other two groups were exposed in triplicate to 1\/20th (0.165\u2009mg\/L) and 1\/10th (0.330\u2009mg\/L) concentration of the 96\u2010h LC\n                    <jats:sub>50<\/jats:sub>\n                    of CBZ (50% wettable powder) for 7 and 14\u2009days. A significant increase (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) in intracellular ROS, micronuclei frequency, and nuclear abnormalities in blood cells was noted with increasing concentration. A decline (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) in RBC, Hb, PCV, and MCHC was observed. Conversely, marked increases (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) in WBC, MCV, and MCH were reported in fish exposed to higher concentrations of pesticide. A significant elevation in liver (ALP, ALT, and AST) and kidney (urea, creatinine, and uric acid) biomarkers was also reported in pesticide CBZ\u2010exposed fish. Histopathological examination revealed a dose\u2010dependent degenerative, necrotic, and inflammatory lesion across the gill, hepatic, renal, muscular, and neural architectures. An elevation in the prevalence percentage and histological alteration indices in response to pesticide CBZ was also observed. The order of histopathological alteration indices in exposed fish was as follows: gill\u2009&gt;\u2009liver\u2009&gt;\u2009kidney\u2009&gt;\u2009brain\u2009=\u2009muscle. The results revealed that the tested concentrations, being environmentally relevant and representative of potential hotspot contamination scenarios, could elicit systemic toxicity in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. striata<\/jats:italic>\n                    <\/jats:styled-content>\n                    and therefore pose a serious risk to aquatic organisms.\n                  <\/jats:p>","DOI":"10.1002\/jat.70014","type":"journal-article","created":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T01:05:28Z","timestamp":1766538328000},"page":"2563-2581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Assessment of ROS\u2010Mediated Genotoxic and Systemic Responses in Fish Exposed to Pesticide Carbendazim Stress"],"prefix":"10.1002","volume":"46","author":[{"given":"Aastha","family":"Dubey","sequence":"first","affiliation":[{"name":"Environmental Toxicology and Bioremediation Laboratory, Department of Zoology University of Lucknow  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arpita\u00a0Shankar","family":"Harnam","sequence":"additional","affiliation":[{"name":"Environmental Toxicology and Bioremediation Laboratory, Department of Zoology University of Lucknow  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Gupta","sequence":"additional","affiliation":[{"name":"Environmental Toxicology and Bioremediation Laboratory, Department of Zoology University of Lucknow  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9895-0685","authenticated-orcid":false,"given":"Manoj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Environmental Toxicology and Bioremediation Laboratory, Department of Zoology University of Lucknow  Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.btre.2022.e00773"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41545\u2010025\u201000434\u2010w"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2020.04.016"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1218(95)90078-0"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010020\u201009931\u20106"},{"key":"e_1_2_12_7_1","volume-title":"Standard Methods for the Examination of Water and Wastewater, 23rd Edition: American Water Works Association","author":"Baird R. 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