{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T13:55:33Z","timestamp":1790258133529,"version":"4.1.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T00:00:00Z","timestamp":1765065600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["20720252008"],"award-info":[{"award-number":["20720252008"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Valproic acid (VPA), a commonly used treatment for epilepsy and psychiatric disorders, is associated with neurodevelopmental toxicity and an elevated risk of autism spectrum disorder (ASD). This study investigates the protective effects of rosiglitazone (RGZ), a peroxisome proliferator\u2010activated receptor (PPAR) agonist, against VPA\u2010induced neurotoxicity in zebrafish larvae. Zebrafish embryos were exposed to VPA (50, 75, 100\u2009\u03bcM) from 0.5\u2010h postfertilization (hpf) to 120\u2009hpf, with or without RGZ cotreatment. VPA exposure significantly reduced locomotor activity, evidenced by decreased swimming distance and velocity, and disrupted neurotransmitter homeostasis, with elevated norepinephrine and L\u2010glutamic acid levels. Transcriptomic analysis and qRT\u2010PCR revealed that VPA downregulated PPAR pathway genes (\n                    <jats:italic>ppara<\/jats:italic>\n                    ,\n                    <jats:italic>pparg<\/jats:italic>\n                    ,\n                    <jats:italic>pck1<\/jats:italic>\n                    , and\n                    <jats:italic>fabp1<\/jats:italic>\n                    ), while RGZ cotreatment partially restored locomotor activity, normalized neurotransmitter levels, and rescued PPAR pathway gene expression. These findings demonstrate that RGZ mitigates VPA\u2010induced neurotoxicity by activating PPAR signaling, restoring metabolic balance, and improving motor function, suggesting PPAR agonists as potential therapeutic agents for VPA\u2010induced neurotoxicity and ASD\u2010related deficits.\n                  <\/jats:p>","DOI":"10.1002\/jat.70031","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T02:58:56Z","timestamp":1765162736000},"page":"2158-2166","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Rosiglitazone Mitigates Valproic Acid\u2010Induced Neurotoxicity in Zebrafish Larvae via Activation of the PPAR Pathway"],"prefix":"10.1002","volume":"46","author":[{"given":"Jian","family":"Guo","sequence":"first","affiliation":[{"name":"Department of Neurosurgery The Fourth Affiliated Hospital of Harbin Medical University  Harbin China"},{"name":"Department of Neurosurgery Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naying","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyu","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Jiang","sequence":"additional","affiliation":[{"name":"Nursing Department Xiang'an Hospital of Xiamen University, School of Medicine, Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingwen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of 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