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Atypical antipsychotics are the most commonly used in clinics, accompanied by adverse metabolic reactions such as increased body mass, metabolic disorders, dyslipidemia, and poor tolerance to glucose stimulation, which always reduce the life expectancy of psychotic patients. Here, we searched the database for original and review articles in English and elucidated the existing mechanisms involved in the pathogenesis of atypical antipsychotic\u2010induced glucose and lipid metabolism disorders, which occur in the hypothalamus, liver, pancreas\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010cells, adipose tissue, and skeletal muscle. Furthermore, we summarized chemical therapeutics such as liraglutide and topiramate, which could be used in combination with atypical antipsychotics against metabolic disorders caused by atypical antipsychotics, providing clues for future research and therapeutic strategy development.\n                  <\/jats:p>","DOI":"10.1002\/jat.70036","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T02:15:21Z","timestamp":1765592121000},"page":"793-807","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Atypical Antipsychotics\u2010Induced Glucose and Lipid Metabolism Disorders and Therapeutic Intervention"],"prefix":"10.1002","volume":"46","author":[{"given":"Aixiao","family":"Xia","sequence":"first","affiliation":[{"name":"Department of Pharmacy Tiantai People's Hospital of Zhejiang Province (Tiantai Branch of Zhejiang Provincial People's Hospital), Hangzhou Medical College  Taizhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Jin","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, Department of Pharmaceutical Sciences Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-7560","authenticated-orcid":false,"given":"Shuwei","family":"Ke","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology, Department of Pharmaceutical Sciences Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3873-4061","authenticated-orcid":false,"given":"Hanbing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Tiantai People's Hospital of Zhejiang Province (Tiantai Branch of Zhejiang Provincial People's Hospital), Hangzhou Medical College  Taizhou Zhejiang China"},{"name":"Institute of Pharmacology, Department of Pharmaceutical Sciences Zhejiang University of Technology  Hangzhou China"},{"name":"Zhejiang Key Laboratory of Green Manufacturing Technology for Chemical Drugs  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junwei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Tiantai People's Hospital of Zhejiang Province (Tiantai Branch of Zhejiang Provincial People's Hospital), Hangzhou Medical College  Taizhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380\u2010022\u201001509\u20107"},{"issue":"3","key":"e_1_2_10_3_1","first-page":"S88","article-title":"Berberine Attenuates Olanzapine Induced\u2010Metabolic Syndrome","volume":"69","author":"Al\u2010Naimi M. 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