{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T09:08:39Z","timestamp":1780304919709,"version":"3.54.0"},"reference-count":25,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,28]],"date-time":"2025-12-28T00:00:00Z","timestamp":1766880000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The use of anesthetics may cause damage to the human nervous system, leading to cognitive and motor dysfunction in severe cases. The role of lncRNAs in anesthesia\u2010induced nerve injury have been reported, but their specific regulatory mechanism remains to be explored. By analyzing the GSE160299 and GSE235357 datasets, LINC01187 was screened as our target lncRNA. With the aid of bioinformatics methods, hsa\u2010miR\u20106069 and IGF2BP3 were predicted as possible downstream molecules of LINC01187. Their expressions were detected by RT\u2010qPCR or western blotting. The dual\u2010luciferase reporter assay was used to determine the targeted association among them. The CCK\u20108, Annexin V\/PI staining, and ROS detection kit were used to evaluate the viability, apoptosis, and oxidative damage of cells. The Rota\u2010Rod and Morris water maze tests were used to measure the motor and learning abilities of rats. LINC01187 showed a low expression in propofol (PPF)\u2013 or ketamine (KTM)\u2013treated human cortex neuron cells (hCNCs) and in the hippocampal tissues of KTM\u2010treated rats. Overexpression therapy with LINC01187 alleviated the damage caused by KTM to the motor and learning abilities of rats. LINC01187 targeted hsa\u2010miR\u20106069 and downregulated it. Hsa\u2010miR\u20106069 inhibited IGF2BP3 expression by binding to its mRNA. The overexpression of LINC01187 rescued the viability decrease, apoptosis increase, and oxidative damage in PPF\/KTM\u2010induced hCNCs by inhibiting hsa\u2010miR\u20106069 to promote IGF2BP3 expression. In conclusion, intrathecal injection therapy of the LINC01187 vector restored the impairment of motor and learning abilities in KTM\u2010treated rats. LINC01187 protected nerve cells and rats from anesthetic\u2010induced impairment by regulating the hsa\u2010miR\u20106069\/IGF2BP3 axis.<\/jats:p>","DOI":"10.1002\/jat.70047","type":"journal-article","created":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T02:31:06Z","timestamp":1766975466000},"page":"2582-2591","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Function of LINC01187 in Anesthetic\u2010Induced Neurological Impairment by Adsorbing hsa\u2010miR\u20106069 to Promote IGF2BP3 Expression"],"prefix":"10.1002","volume":"46","author":[{"given":"Wei","family":"Zhang","sequence":"first","affiliation":[{"name":"Anesthesiology Department Zhongshan Hospital Affiliated to Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiyuan","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Renmin Hospital of Wuhan University  Wuhan 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