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Organoid\u2010based platforms advance preclinical testing by providing an accurate representation of human tissue architecture and genetics, surpassing traditional two\u2010dimensional cultures and animal models in testing both drug safety and efficacy. Researchers are shifting toward organoid\u2010based systems as primary components of new approach methodologies, as global regulatory bodies increasingly acknowledge animal testing limitations. This review delivers an exhaustive examination of organoid technologies and their applications in drug testing. Our study explores current methods used to model toxic responses in different organs\u2014such as the liver, kidney, and heart\u2014while highlighting how personalized and disease\u2010specific organoids can enhance the accuracy of efficacy testing. Our investigation also examines regulatory frameworks and outlines the path toward organoid platform standardization and validation before their integration into drug development processes. 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