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The physiological, biochemical and histological consequences of long\u2010term TCS exposure in\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Oreochromis niloticus<\/jats:italic>\n                    <\/jats:styled-content>\n                    were assessed in this study. For 15, 30 and 45\u2009days, adult fish were exposed to three sublethal doses of TCS (0.146, 0.219 and 0.438\u2009mg\u2009L\n                    <jats:sup>\u22121<\/jats:sup>\n                    ). To ascertain reproductive and hepatic responses, growth indices, hepatosomatic index (HSI), gonadosomatic index (GSI), plasma vitellogenin (VTG) levels and gonadal histopathology were evaluated. The results showed significant increases in HSI and decreases in GSI, indicating hepatic enlargement and gonadal suppression, along with concentration\u2010dependent declines in body weight and total length. Biochemical investigations revealed significant changes in VTG synthesis, with males displaying a brief increase followed by suppression and females showing a dose and time\u2010dependent reduction, indicating a dualistic, sex\u2010specific endocrine response. Reproductive impairment was confirmed by histopathological testing, which revealed severe degenerative alterations in gonadal tissues, including necrosis, vacuolation, interstitial cell infiltration and follicular atresia. Potential effects on breeding fitness, offspring production and population stability are suggested by the incapacity of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>O.\u2009niloticus<\/jats:italic>\n                    <\/jats:styled-content>\n                    to tolerate TCS\u2010induced stress during the spawning period. All of these results point to triclosan being a strong endocrine and cytotoxic drug that interferes with the hepatic and gonadal physiology of\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>O.\u2009niloticus<\/jats:italic>\n                    <\/jats:styled-content>\n                    . The study highlights the critical need for more stringent regulation and monitoring of this molecule in aquatic habitats, as well as the ecological risk connected to persistent TCS contamination.\n                  <\/jats:p>","DOI":"10.1002\/jat.70070","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T06:56:10Z","timestamp":1768978570000},"page":"2766-2778","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Toxicity Assessment and Plasma Vitellogenin Expression in Nile Tilapia (\n                    <scp>\n                      <i>Oreochromis niloticus<\/i>\n                    <\/scp>\n                    ) Exposed to an Endocrine Disruptor, Triclosan"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-6694-098X","authenticated-orcid":false,"given":"Raj","family":"Sunu","sequence":"first","affiliation":[{"name":"Department of Zoology University of Kerala  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1104-0617","authenticated-orcid":false,"given":"G.","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Zoology University of Kerala  Thiruvananthapuram Kerala India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.21608\/ejabf.2018.28005"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10653\u2010024\u201002226\u20106"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.140461"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmars.2021.758868"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-99-5340-0_17"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025\u2010326X(01)00062\u20105"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dib.2021.107625"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.2989\/16085914.2020.1746233"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.33003\/fjs\u20102025\u20100902\u20102742"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1065\/espr2007.05.426"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.3c01922"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356\u2010023\u201031295\u2010w"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jfd.13469"},{"key":"e_1_2_11_15_1","unstructured":"Daniel M.2009. \u201cEstrogens in Environment Their Impact on Male Fertility.\u201d"},{"key":"e_1_2_11_16_1","first-page":"207","volume-title":"Pollution and Fish Health in Tropical Ecosystems","author":"Oliveira Ribeiro C. 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