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In the present study, it was investigated whether high\u2010density polyethylene (HDPE)\u2010MPs exacerbate the toxicological effects of the pyrethroid insecticide deltamethrin in juvenile common carp (\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Cyprinus carpio<\/jats:italic>\n                    <\/jats:styled-content>\n                    ). Fish (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009270; 25\u2009\u00b1\u20095\u2009g) were randomly allocated to a 2\u2009\u00d7\u20093 factorial design (three replicates per group; 15 fish per tank) and exposed for 30\u2009days to sub\u2010lethal deltamethrin (12.5\u2009\u03bcg\/L; 10% of 96\u2010h LC\u2085\u2080) and\/or HDPE\u2010MPs (0, 350, or 700\u2009\u03bcg\/L; 200\u2013250\u2009\u03bcm). Hepatic detoxification\u2010 and antioxidant\u2010related gene expression was quantified, together with redox status, oxidative damage, and plasma biochemical biomarkers of organ function and injury. Deltamethrin and MPs alone altered transcriptional and biochemical endpoints, while co\u2010exposure (particularly with 700\u2009\u03bcg\/L MPs) produced the most pronounced responses, including stronger induction of detoxification\/metal\u2010binding genes, reduced overall antioxidant capacity, and marked increases in lipid peroxidation and protein oxidation. Plasma activities of AST, ALT, ALP, LDH, GGT, and CK increased, and butyrylcholinesterase was inhibited, indicating cellular membrane damage and multi\u2010organ dysfunction. Changes in circulating metabolites and creatinine further supported hepatic and renal impairment, and significant interaction effects for multiple endpoints suggested potentiation of deltamethrin toxicity by MPs. Overall, HDPE MPs act as relevant co\u2010stressors that intensify deltamethrin\u2010driven toxicity in fish, underscoring the need for mixture\u2010aware monitoring and risk assessment in contaminated freshwater environments.\n                  <\/jats:p>","DOI":"10.1002\/jat.70072","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T05:42:52Z","timestamp":1769146972000},"page":"2803-2818","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Evaluation of Detoxification\u2010Related Gene Expression, Oxidative Stress Biomarkers, and Blood Biochemical Parameters in Common Carp (\n                    <scp>\n                      <i>Cyprinus carpio<\/i>\n                    <\/scp>\n                    ) Co\u2010Exposed to Polyethylene Microplastics and 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