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The\n                    <jats:italic>S. platensis<\/jats:italic>\n                    extract was optimized at a concentration of 0.5%, stored at 4\u00b0C and centrifuged at 6000\u2009rpm for 5\u2009min. Ultraviolet\u2013visible spectroscopy of the extract showed a broad absorbance band in the 330\u2010 to 380\u2010nm region and a shoulder in the 520\u2010 to 620\u2010nm range, corresponding to bioactive metabolites. The formation of silver\u2010zinc oxide nanocomposites was confirmed by characteristic absorbance in the 300\u2010 to 400\u2010nm region under optimized conditions. Particle size analysis using a Zetasizer revealed an average particle size of approximately 204\u2009nm with a polydispersity index of 0.28. Functional groups, crystallinity, and surface morphology were characterized using Fourier transform infrared spectroscopy, X\u2010ray diffraction, and scanning electron microscopy. Due to increasing concerns over antibiotic resistance, the antibacterial potential of the synthesized nanocomposites was evaluated by the disk diffusion method showing a maximum zone of inhibition of 35\u2009\u00b1\u20090.4\u2009nm against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Pseudomonas aeruginosa<\/jats:italic>\n                    <\/jats:styled-content>\n                    at 13\u2009\u03bcg\/mL. The Ag\u2010ZnO nanocomposites exhibited a notable antioxidant activity, indicating a concentration\u2010dependent DPPH radical scavenging activity with a maximum inhibition of 67.3% at 517\u2009nm, compared to 60.12 for ascorbic acid. Furthermore, cytotoxic evaluation against the BT\u2010549 breast cancer cell line revealed a half\u2010maximal inhibitory concentration (IC\n                    <jats:sub>50<\/jats:sub>\n                    ) of 6.401\u2009\u03bcg\/mL. These findings indicate that\n                    <jats:italic>S. platensis<\/jats:italic>\n                    \u2013mediated silver\u2010zinc oxide nanocomposites exhibit promising biological activity.\n                  <\/jats:p>","DOI":"10.1002\/jat.70138","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:31:37Z","timestamp":1773037897000},"page":"3814-3828","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Green Synthesis of Silver\u2010Zinc Oxide Nanocomposites Using\n                    <i>Spirulina platensis<\/i>\n                    Biomass: Characterization and Biomedical Evaluation"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1049-0480","authenticated-orcid":false,"given":"Muhammad\u00a0Usman","family":"Ahmad","sequence":"first","affiliation":[{"name":"Department of Microbiology, Dr. Ikram\u2010ul\u2010Haq Institute of 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