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Herein, the effects of lung injury were evaluated both in\u00a0vivo and in\u00a0vitro; meanwhile, the metabolomics and proteomics methodologies were employed to elucidate the intracellular mechanisms of BEAS\u20102B cells. The results showed that MEHP treatment significantly decreased cell viability and caused inflammation and fibrosis changes in\u00a0vivo and in\u00a0vitro, manifested as abnormal expression of associated genes. There were 26 upregulated and 8 downregulated metabolites found in BEAS\u20102B cells exposed to MEHP, which mainly focused on fatty acid metabolism pathways. In addition, the tricarboxylic acid (TCA) cycle, alanine, aspartate, and glutamate metabolism, purine metabolism, butanoate metabolism, and ribosome synthesis are also important events in DEHP pathophysiology. Furthermore, proteomics methodologies and correlation analysis show that PLIN2 and HMGCS1 may be involved in the fatty acid synthesis pathway. These results expand the existing understanding of the molecular basis of DEHP\u2010induced lung injury and progression, offering a new perspective for exploring its pathological mechanisms.<\/jats:p>","DOI":"10.1002\/jat.70153","type":"journal-article","created":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T14:36:37Z","timestamp":1773758197000},"page":"3921-3932","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Analysis of Metabolomics and Proteomics Reveals the Potential Mechanism of Lung Injury Induced by Di(2\u2010Ethylhexyl) Phthalate"],"prefix":"10.1002","volume":"46","author":[{"given":"Siya","family":"Wu","sequence":"first","affiliation":[{"name":"Henan Office for Cancer Control and Research, Henan International Joint Laboratory of Cancer Prevention, Henan Engineering Research Center of Cancer Prevention and Control The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer 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