{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:55:12Z","timestamp":1790848512704,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T00:00:00Z","timestamp":1773964800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    This study investigated the effects of green\u2010synthesized zinc oxide (ZnO\u2010NPs) and selenium nanoparticles (Se\u2010NPs) on oxidative stress, inflammation, and histopathology in Japanese quail. The NPs were synthesized using extracts from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Moringa oleifera<\/jats:italic>\n                    <\/jats:styled-content>\n                    (MrOl) and\n                    <jats:italic>Agaricus bisporus<\/jats:italic>\n                    (AaBi). One\u2010day\u2010old quails (six per group) were assigned to a control and each of 16 treatment groups receiving dietary supplementation with varying doses of ZnO\u2010NPs (20\u201380\u2009mg\/kg) and Se\u2010NPs (0.05\u20130.30\u2009mg\/kg) for 5\u2009weeks. Biochemical, hematological, oxidative stress biomarkers, and gene expression (Nrf\u20102, IL\u20106) were analyzed, and histopathological examinations of the liver, kidney, and spleen were conducted. Results showed that optimal doses of MrOl\u2010synthesized NPs, particularly Se\u2010MrOl, significantly improved antioxidant status (reduced MDA, increased GSH), upregulated Nrf\u20102, downregulated IL\u20106, and enhanced lipid profiles (increased HDL) without causing significant histopathological damage. In contrast, higher doses, especially of AaBi\u2010synthesized NPs, induced oxidative stress, inflammation, and mild tissue alterations. The study concludes that green\u2010synthesized ZnO and Se\u2010NPs, particularly from MrOl at optimized doses, can enhance antioxidant defenses and modulate immune responses in quail, highlighting their potential as effective nutritional supplements in poultry production.\n                  <\/jats:p>","DOI":"10.1002\/jat.70158","type":"journal-article","created":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T08:11:33Z","timestamp":1773994293000},"page":"4025-4043","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Exposure to Zinc Oxide and Selenium Nanoparticles in Japanese Quail: Oxidative Stress, Inflammatory Responses, and Histopathological Outcomes"],"prefix":"10.1002","volume":"46","author":[{"given":"Tuba","family":"Noreen","sequence":"first","affiliation":[{"name":"Department of Zoology, Division of Science and Technology University of Education  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Mansha","sequence":"additional","affiliation":[{"name":"Department of Zoology, Division of Science and Technology University of Education  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jibran","family":"Hussain","sequence":"additional","affiliation":[{"name":"Department of Poultry Production University of Veterinary and Animal Science  Lahore Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-021-02662-w"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ani11071916"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2024.109452"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.2903\/j.efsa.2012.2970"},{"issue":"2","key":"e_1_2_8_6_1","article-title":"Safety and Efficacy of Selenium Compounds (E8) as Feed Additives for All Animal Species: Sodium Selenite, Based on a Dossier Submitted by Retorte GmbH Selenium Chemicals and Metals","volume":"14","author":"Additives, E. 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