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This study explored the potential of BPA and NP to drive neuronal injury and ferroptosis linked to oxidative stress, acting through the transient receptor potential melastatin 2 (TRPM2)\u2013poly (ADP\u2010ribose) polymerase\u20101 (PARP1) signaling axis. Forty\u2010two adult male Wistar rats were allocated into seven groups (control, low\u2010dose [25\u2009mg\/kg]\/high\u2010dose [100\u2009mg\/kg] BPA, low\u2010dose [25\u2009mg\/kg]\/high\u2010dose [100\u2009mg\/kg] NP, and low\u2010dose [25\u2009mg\/kg]\/high\u2010dose [100\u2009mg\/kg] BPA\u2009+\u2009NP) and treated orally for 21\u2009days. We employed a combinatorial approach of biochemical assays and immunohistochemistry to evaluate oxidative stress markers, ferroptosis hallmarks (glutathione peroxidase 4 [GPX4], solute carrier family 7 member 11 [SLC7A11], and transferrin receptor [TfRC]), apoptotic mediators (Caspase\u20103 and Caspase\u20109), and inflammatory cytokines, as well as the expression of TRPM2 and PARP\u20101. Results demonstrated that BPA and NP exposure triggered a robust, dose\u2010dependent accumulation of reactive oxygen species (ROS) and lipid peroxidation, concomitant with downregulation of anti\u2010ferroptotic proteins (GPX4 and SLC7A11) and upregulation of TfRC. This toxic insult simultaneously activated apoptotic and inflammatory cascades. Crucially, TRPM2 and PARP\u20101 were significantly upregulated, implying a potential role for the TRPM2\u2013PARP\u20101 axis as an upstream modulator of oxidative stress\u2010induced ferroptosis and neuroinflammation. Collectively, these findings provide novel mechanistic insights into phenol\u2010induced neurotoxicity, highlighting the inhibition of the TRPM2\u2013PARP\u20101 axis as a promising therapeutic strategy to mitigate environmental neurodegeneration in sensory neurons.<\/jats:p>","DOI":"10.1002\/jat.70245","type":"journal-article","created":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T05:39:52Z","timestamp":1780033192000},"page":"3660-3674","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The TRPM2\u2013PARP\u20101 Axis Involvement in Bisphenol A and Nonylphenol\u2010Induced Ferroptosis in Trigeminal Ganglion Cells"],"prefix":"10.1002","volume":"46","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4029-2007","authenticated-orcid":false,"given":"Bet\u00fcl","family":"Yaz\u011fan","sequence":"first","affiliation":[{"name":"Department of Physiology, Faculty of Medicine Kastamonu University  Kastamonu 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