{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T02:59:18Z","timestamp":1781319558337,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:00:00Z","timestamp":1781222400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The interaction between fatty acids and nanoparticles (NPs) is increasingly recognized. This study investigated how stearic acid (SA)\/linolenic acid (LNA) and SiO\n                    <jats:sub>2<\/jats:sub>\n                    NPs co\u2010exposure affects mRNA abundance of efflux, autophagy, fatty acid metabolism, and synthesis genes in adult zebrafish, and Si concentrations and lipid accumulation in Caco\u20102 and HepG2 cells. In\u00a0vivo, SA or LNA inhibited SiO\n                    <jats:sub>2<\/jats:sub>\n                    NPs from inducing\n                    <jats:italic>abcg1<\/jats:italic>\n                    expression, and SiO\n                    <jats:sub>2<\/jats:sub>\n                    NPs and SA\/LNA co\u2010exposure decreased\n                    <jats:italic>agap1<\/jats:italic>\n                    expression in intestines. In livers, SiO\n                    <jats:sub>2<\/jats:sub>\n                    NPs and SA co\u2010exposure increased\n                    <jats:italic>abcg1<\/jats:italic>\n                    expression. SiO\n                    <jats:sub>2<\/jats:sub>\n                    NPs increased autophagic gene expression (\n                    <jats:italic>map 1lc3b<\/jats:italic>\n                    ,\n                    <jats:italic>atg7<\/jats:italic>\n                    , and\n                    <jats:italic>becn1<\/jats:italic>\n                    ) in intestines but not in livers. In contrast, SiO\n                    <jats:sub>2<\/jats:sub>\n                    NPs\u2009+\u2009LNA increased\n                    <jats:italic>map 1lc3b<\/jats:italic>\n                    and\n                    <jats:italic>atg7<\/jats:italic>\n                    expression, and SiO\n                    <jats:sub>2<\/jats:sub>\n                    NPs\u2009+\u2009SA increased\n                    <jats:italic>atg5<\/jats:italic>\n                    and\n                    <jats:italic>becn1<\/jats:italic>\n                    expression in livers. For fatty acid \u03b2\u2010oxidation genes, SiO\n                    <jats:sub>2<\/jats:sub>\n                    NPs increased\n                    <jats:italic>acox1<\/jats:italic>\n                    expression but decreased\n                    <jats:italic>pparaa<\/jats:italic>\n                    expression in intestines, an effect altered by SA or LNA. In livers, SiO\n                    <jats:sub>2<\/jats:sub>\n                    NPs decreased\n                    <jats:italic>acox1<\/jats:italic>\n                    ,\n                    <jats:italic>cpt1aa<\/jats:italic>\n                    , and\n                    <jats:italic>pparaa<\/jats:italic>\n                    but increased\n                    <jats:italic>pnpla2<\/jats:italic>\n                    expression, which was also changed by SA. For fatty acid synthesis genes, LNA increased\n                    <jats:italic>acaca<\/jats:italic>\n                    and\n                    <jats:italic>fasn<\/jats:italic>\n                    expression in SiO\n                    <jats:sub>2<\/jats:sub>\n                    NP\u2010exposed intestines. In livers, SiO\n                    <jats:sub>2<\/jats:sub>\n                    NPs decreased\n                    <jats:italic>acaca<\/jats:italic>\n                    ,\n                    <jats:italic>fasn<\/jats:italic>\n                    , and\n                    <jats:italic>scd<\/jats:italic>\n                    expression, which was increased by LNA. In\u00a0vitro, LNA increased Si accumulation in SiO\n                    <jats:sub>2<\/jats:sub>\n                    NP\u2010exposed Caco\u20102 cells, whereas both fatty acids reduced Si levels in HepG2 cells. Lipid accumulation was enhanced in HepG2 cells exposed to LNA and SiO\n                    <jats:sub>2<\/jats:sub>\n                    NPs\u2009+\u2009LNA. Overall, our findings highlighted the complex interplay between SiO\n                    <jats:sub>2<\/jats:sub>\n                    NPs and fatty acids, with outcomes dependent on fatty acid structure and cell\/tissue type.\n                  <\/jats:p>","DOI":"10.1002\/jat.70270","type":"journal-article","created":{"date-parts":[[2026,6,13]],"date-time":"2026-06-13T02:30:46Z","timestamp":1781317846000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Influences of Co\u2010Exposure to Fatty Acids and SiO\n                    <sub>2<\/sub>\n                    Nanoparticles on Gene Expression in Zebrafish Intestines and Livers and Si Accumulation and Lipid Staining in Caco\u20102 and HepG2 Cells"],"prefix":"10.1002","author":[{"given":"Weiqi","family":"Lin","sequence":"first","affiliation":[{"name":"Hunan Province Key Laboratory of Typical Environmental Pollution and Health Hazards, School of Public Health, 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