{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:58:41Z","timestamp":1787795921672,"version":"build-2784847793"},"reference-count":59,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In this study, the structural, surface, dielectric, biological, and functional properties of biogenically synthesized silver nanoparticles (AH\u2010AgNPs) produced using Anzer honey (AH) were comprehensively investigated. Physicochemical characterization revealed that the nanoparticles exhibited frequency\u2010dependent dielectric behavior, with the dielectric constant decreasing from approximately 8.8 to 6.0 as frequency increased, while AC conductivity increased markedly. Surface analyses yielded a total free energy of 38.393\u2009mN\/m (23.295\u2009mN\/m dispersive, 15.098\u2009mN\/m polar) and moderate wettability (67.58\u00b0 water; 59.32\u00b0 DMF), indicating the presence of bioactive organic coatings. Biological assays demonstrated potent antimicrobial activity, particularly against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>C. albicans<\/jats:italic>\n                    <\/jats:styled-content>\n                    , and significant photocatalytic efficiency, with methylene blue degradation reaching 21% within 90\u2009min. Notably, AH\u2010AgNPs showed selective cytotoxicity: At 5\u2009\u03bcg\/mL, doses were non\u2010toxic to healthy L929 fibroblasts, whereas cell viability decreased significantly in A549 lung cancer cells. This anticancer effect was primarily mediated by oxidative stress, as evidenced by a marked increase in TOS (from 9 to 81.79\u2009\u03bcmol H\n                    <jats:sub>2<\/jats:sub>\n                    O\n                    <jats:sub>2<\/jats:sub>\n                    eq\/g) and OSI (32.90 to 446.51\u2009AU) at higher concentrations. Furthermore, in the wound\u2010healing model, the wound closure rate was 68.49% in the AH group, increasing to 73.89% in the AH\u2010AgNP\u2010treated group, representing one of the most striking outcomes of the study and suggesting enhanced cell migration and proliferation in the presence of nanoparticles. These multifunctional properties\u2014combining distinctive dielectric characteristics, low cytotoxicity to healthy cells, selective anticancer activity, and environmental remediation potential\u2014position these biogenic AH\u2010AgNPs as promising candidates for advanced biomedical and environmental applications.\n                  <\/jats:p>","DOI":"10.1002\/jat.70284","type":"journal-article","created":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T03:58:28Z","timestamp":1781582308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Green\u2010Synthesized Anzer Honey\u2010Derived Silver Nanoparticles: Selective Cytotoxic Effects, Oxidative Stress, and Biocompatibility"],"prefix":"10.1002","author":[{"given":"Ahmet","family":"B\u00fcy\u00fckben","sequence":"first","affiliation":[{"name":"Department of Chemistry Technology, \u00c7ay Vocational School Afyon Kocatepe University  Afyonkarahisar 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