{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:52:56Z","timestamp":1781761976078,"version":"3.54.5"},"reference-count":67,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:00:00Z","timestamp":1781654400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002383","name":"King Saud University","doi-asserted-by":"publisher","award":["ORF\u20102026\u201017"],"award-info":[{"award-number":["ORF\u20102026\u201017"]}],"id":[{"id":"10.13039\/501100002383","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Angiotensin II receptor antagonists (ARBs), such as losartan, are widely prescribed for the management of hypertension and various cardiovascular disorders. However, their potential effects on female fertility remain largely unexplored. This study aimed to investigate the impact of losartan on ovarian function and fertility in female Wistar albino rats. Rats were orally administered low (0.7\u2009mg\/kg) and high (1.4\u2009mg\/kg) doses of losartan daily for 1\u2009month. Following the treatment period, ovaries were collected, weighed, fixed, and subjected to comprehensive analysis for markers associated with folliculogenesis and steroidogenesis. Specifically, histopathological, immunofluorescence, RT\u2010PCR, and in silico analyses were performed on ovarian tissues. The results demonstrated a significant reduction in fertility rates, accompanied by notable alterations in follicular development and ovarian histoarchitecture. Furthermore, losartan treatment led to a decreased expression of Cyp19 while concurrently increasing the expression of estrogen receptor genes,\n                    <jats:italic>Esr1<\/jats:italic>\n                    and\n                    <jats:italic>Esr2<\/jats:italic>\n                    , and insulin\u2010like growth factor 1 (\n                    <jats:italic>Igf1<\/jats:italic>\n                    ). Crucially, the mRNA expression levels of anti\u2010M\u00fcllerian hormone (\n                    <jats:italic>Amh<\/jats:italic>\n                    ), a reliable indicator of ovarian reserve, were disrupted. Biochemical analyses revealed reduced glutathione levels and increased malondialdehyde levels, further indicating oxidative stress and ovarian cellular damage, consistent with the observed histopathological findings. In silico docking studies provided insights into potential molecular mechanisms, revealing interactions between losartan, microRNA\u2010129\u20101\u20103p, and the mRNA expression levels of\n                    <jats:italic>Esr1<\/jats:italic>\n                    and\n                    <jats:italic>Esr2<\/jats:italic>\n                    , which may contribute to the observed molecular changes. These findings collectively underscore the detrimental impact of losartan on ovarian health and highlight the urgent need for further comprehensive research into its effects on female reproductive health.\n                  <\/jats:p>","DOI":"10.1002\/jat.70286","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T05:05:52Z","timestamp":1781759152000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Angiotensin II Receptor Antagonist Losartan Impairs Female Fertility in Rats: Potential Mediating Role of microRNA\u2010129\u20101\u20103p"],"prefix":"10.1002","author":[{"given":"Safieah","family":"Alhaddawi","sequence":"first","affiliation":[{"name":"Department of Zoology, College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saber","family":"Nahdi","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moez","family":"Ayadi","sequence":"additional","affiliation":[{"name":"Department of Animal Production, College of Food and Agriculture Sciences King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jilani Purusottapatnam","family":"Shaik","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh","family":"Alwasel","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2170-1303","authenticated-orcid":false,"given":"Abdel Halim","family":"Harrath","sequence":"additional","affiliation":[{"name":"Department of Zoology, College of Science King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12958-015-0032-1","article-title":"A Unique View on Male Infertility Around the Globe","volume":"13","author":"Agarwal A.","year":"2015","journal-title":"Reproductive Biology and Endocrinology"},{"key":"e_1_2_10_3_1","first-page":"1","article-title":"Losartan Ameliorates Premature Ovarian Failure by Regulation of the Sirti1\/NF\u2010\u03baB Pathway in Female Albino Rats","volume":"48","author":"Al\u2010Gholam M. 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