{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T01:46:10Z","timestamp":1782524770028,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100009972","name":"Aksaray \u00dcniversitesi","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009972","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Dexamethasone (DEX) is widely used in clinical practice, although it may also cause oxidative stress\u2013related damage in different tissues, including the kidney and male reproductive system. This study investigated DEX\u2010induced renal and reproductive injury in rats and evaluated the modulatory effect of reduced glutathione on DEX\u2010associated redox imbalance and tissue injury. Thirty\u2010five adult male Wistar rats were divided into five groups (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20097): control, DEX (7\u2009mg\/kg\/day, intraperitoneally, for 7\u2009days), GSH (0.2\u2009g\/kg\/day, oral gavage, for 7\u2009days), co\u2010administration (DEX\u2009+\u2009GSH for 7\u2009days; DG7), and extended treatment (DEX\u2009+\u2009GSH for 7\u2009days followed by seven additional days of GSH; DG14). Spermatological parameters, chlortetracycline\u2010based capacitation status, total antioxidant status (TAS) and total oxidant status (TOS) in epididymal sperm samples, and histopathological changes in the kidney, testis, and epididymis were evaluated. DEX impaired sperm motility, concentration, and capacitation, decreased TAS, increased TOS, and caused marked renal and testicular histopathological alterations, including increased collagen deposition, disruption of seminiferous tubule architecture, and reduced spermatogenic activity. GSH attenuated these changes, and the DG14 regimen was associated with the most evident overall improvement. These findings suggest that DEX exposure was associated with redox imbalance and renal and male reproductive alterations, while prolonged GSH administration may modulate glutathione sensitive redox changes related to DEX\u2010induced tissue injury.\n                  <\/jats:p>","DOI":"10.1002\/jat.70303","type":"journal-article","created":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:59:52Z","timestamp":1782521992000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Redox\u2010Associated Renal and Male Reproductive Alterations Following Dexamethasone Exposure in Male Rats: Histopathological and Spermatological Evaluations"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0566-0684","authenticated-orcid":false,"given":"Caner","family":"\u00d6zt\u00fcrk","sequence":"first","affiliation":[{"name":"Department of Reproduction and Artificial Insemination, Faculty of Veterinary Medicine Aksaray University  Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9039-555X","authenticated-orcid":false,"given":"Ne\u015fe Hayat","family":"Aksoy","sequence":"additional","affiliation":[{"name":"Department of Biochemistry, Faculty of Veterinary Medicine Aksaray University  Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5251-2302","authenticated-orcid":false,"given":"Erkan","family":"\u00d6zkan","sequence":"additional","affiliation":[{"name":"Department of Parasitology, Faculty of Veterinary Medicine Aksaray University  Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0716-5695","authenticated-orcid":false,"given":"Ay\u015fe","family":"Ikinci Kele\u015f","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Faculty of Medicine Aksaray University  Aksaray Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7620-2085","authenticated-orcid":false,"given":"Ahmet","family":"Karabulut","sequence":"additional","affiliation":[{"name":"Konya Veterinary Control Institute Directorate  Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43188\u2010024\u201000270\u2010z"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11020306"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.1.1.6843"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/frph.2022.822257"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2017.69"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14081013"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.4067\/S0717\u201095022025000401321"},{"key":"e_1_2_11_9_1","first-page":"2","article-title":"Modulation of Dexamethasone\u2010Induced Testicular Dysfunction by Garcinia kola Seeds\u2010Derived Kolaviron in Rats","volume":"1","author":"Enaiho S. O.","year":"2024","journal-title":"FUOYE Journal of Biomedical Research"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2003.11.015"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2005.08.008"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.102071"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2008.08.006"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10010039"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.29252\/ijrr.19.1.135"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13002"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735\u2010024\u201010317\u2010y"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.31797\/vetbio.1130201"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00105"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.799294"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13955"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.4103\/1008\u2010682X.153303"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox14060720"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0086057"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.14202\/vetworld.2025.1479\u20101486"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14010137"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394\u2010014\u20100706\u2010z"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14231892"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/0960327118816137"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163\u20107258(02)00297\u20108"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/andr.12366"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2021.0117"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.12088"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmn004"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1520835"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.15212\/AMM\u20102022\u20100005"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9020170"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adk5005"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.70303","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jat.70303","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.70303","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T00:59:53Z","timestamp":1782521993000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.70303"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,26]]},"references-count":37,"alternative-id":["10.1002\/jat.70303"],"URL":"https:\/\/doi.org\/10.1002\/jat.70303","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,26]]},"assertion":[{"value":"2026-05-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jat.70303"}}