{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:04:52Z","timestamp":1784271892398,"version":"3.55.0"},"reference-count":101,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["analyticalsciencejournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Applied Toxicology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Aflatoxin B1 causes renal, hepatic, and reproductive disorders. To investigate the protective effects of melatonin\u2010zinc metal\u2013organic frameworks (Mt\u2010Zn\u2010MOFs) nanoparticles against renal, hepatic, and reproductive toxicity induced by aflatoxins B1, male Sprague\u2013Dawley rats (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200940) were equally divided into control, Mt\u2010Zn\u2010MOFs, aflatoxins, and Mt\u2010Zn\u2010MOFs\u2009+\u2009aflatoxins groups. Blood and tissue samples were collected from the livers, kidneys, and testicles. Luteinizing hormone (LH), testosterone, estradiol (E2), interleukin\u2010\u03b2 (IL\u2010\u03b2), transforming growth factor\u2010\u03b2 (TGF\u2010\u03b2), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), total antioxidants (TAC), nitric oxide (NO), AST, ALT, and creatinine were measured. Hepatic DNA fragmentation and the expression of CRAT, CYP39A1, and JunB genes were determined. Mt\u2010Zn\u2010MOFs have more antimycotic effects against\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A. flavus<\/jats:italic>\n                    <\/jats:styled-content>\n                    than\n                    <jats:italic>\n                      <jats:styled-content style=\"fixed-case\">A. parasiticus<\/jats:styled-content>\n                      ,\n                    <\/jats:italic>\n                    with MIC and MFC of 3.125 and 6.25\u2009mg\/mL for\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A. flavus<\/jats:italic>\n                    <\/jats:styled-content>\n                    and 12.5 and 25\u2009mg\/mL for\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A. parasiticus<\/jats:italic>\n                    <\/jats:styled-content>\n                    , and 6.25\u2009mg\/mL inhibited\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A. flavus<\/jats:italic>\n                    <\/jats:styled-content>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>A. parasiticus<\/jats:italic>\n                    <\/jats:styled-content>\n                    sporulation. Mt\u2010Zn\u2010MOFs rats had high (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001) testosterone, LH, E2, glucose, but low (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) SOD, total proteins, albumin, globulin, AST, and ALT, compared to controls. Mt\u2010Zn\u2010MOFs\u2010aflatoxin group had lower (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) LH, SOD, GPx, total proteins, globulin, glucose, TGF\u2010\u03b2 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.022), DNA fragmentation, and the expressions of JunB, CYP39A1, and CRAT, but high (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) NO, CAT, and total cholesterol than aflatoxin\u2010treated rats. Mt\u2010Zn\u2010MOFs protected the liver, kidney, and spermatogenesis to a large extent. Mt\u2010Zn\u2010MOFs maintained normal testicular, hepatic, and renal histopathology in the aflatoxin treatment. Regardless, aflatoxin caused severe renal toxicity, Mt\u2010Zn\u2010MOFs reversed the effects of toxins and restored their normality, and are recommended to treat aflatoxicosis and mycotic infections.\n                  <\/jats:p>","DOI":"10.1002\/jat.70341","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:30:40Z","timestamp":1784269840000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Melatonin\u2010Zinc MOFs Antimycotic, Molecular, and Antioxidant Protective Effects of Hepatic, Renal, and Testicular Dysfunctions Induced by Aflatoxin B1 in Rats"],"prefix":"10.1002","author":[{"given":"Mohamed S.","family":"Aly","sequence":"first","affiliation":[{"name":"Animal Reproduction and Artificial Insemination Department, Veterinary Research Institute National Research Centre  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona M. H.","family":"Soliman","sequence":"additional","affiliation":[{"name":"Microbiology and Immunology Department, Veterinary Research Institute National Research Centre  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esraa A.","family":"Balabel","sequence":"additional","affiliation":[{"name":"Cell Biology Department, Biotechnology Research Institute National Research Centre  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reda M.","family":"Abdelhameed","sequence":"additional","affiliation":[{"name":"Applied Organic Chemistry Department, Chemical Industries Research Institute National Research Centre  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-6130","authenticated-orcid":false,"given":"Amal M.","family":"Aboelmaaty","sequence":"additional","affiliation":[{"name":"Animal Reproduction and Artificial Insemination Department, Veterinary Research Institute National Research Centre  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karima F.","family":"Mahrous","sequence":"additional","affiliation":[{"name":"Cell Biology Department, Biotechnology Research Institute National Research Centre  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2023.122276"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxres\/tfae083"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S385914"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e21837"},{"key":"e_1_2_9_6_1","doi-asserted-by":"crossref","first-page":"53158","DOI":"10.1007\/s11356-022-19324-6","article-title":"Pathological Effects of Graded Doses of Aflatoxin B1 on the Development of the Testes in Juvenile White Leghorn Males","volume":"29","author":"Ashraf A.","year":"2022","journal-title":"Environmental Science and Pollution Research International"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2003.09.001"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/c1nj20202b"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10450\u2010018\u201000002\u20104"},{"key":"e_1_2_9_10_1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.2174\/1874609813666200711153223","article-title":"Melatonin and Regulation of Immune Function, Impact on Numerous Diseases","volume":"13","author":"Bondy S. C.","year":"2020","journal-title":"Current Aging Science"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1098\/rsos.170654"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2011.08.037"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10071010"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.micromeso.2012.06.012"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378\u20104320(89)90004\u20103"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemrestox.8b00202"},{"key":"e_1_2_9_17_1","first-page":"197","article-title":"Temporal Patterns of Covalent DNA Adduct in Rat Liver After Single and Multiple Doses of Aflatoxin B1","volume":"41","author":"Croy R. G.","year":"1981","journal-title":"Cancer Research"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00578296"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13121528"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v28.i36.5250"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/coatings12121864"},{"issue":"4","key":"e_1_2_9_22_1","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.chnaes.2022.08.006","article-title":"Comparison of Poison Plate and Agar Well Diffusion Method Determining the Antifungal Activity of Protein Fractions","volume":"43","author":"Erhonyota C.","year":"2023","journal-title":"Acta Ecologica Sinica"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.13886"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02784623"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imlet.2019.09.001"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jiec.2024.07.025"},{"key":"e_1_2_9_27_1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1006\/gyno.1997.4637","article-title":"Apoptosis as a Measure of Chemosensitivity to Cisplatin and Taxol Therapy in Ovarian Cancer Cell Lines","volume":"65","author":"Gibb R. K.","year":"1997","journal-title":"Gynecologic Oncology"},{"key":"e_1_2_9_28_1","doi-asserted-by":"crossref","DOI":"10.1186\/s40170-024-00335-5","article-title":"BCAA Metabolism in Pancreatic Cancer Affects Lipid Balance by Regulating Fatty Acid Import Into Mitochondria","volume":"12","author":"Gotvaldov\u00e1 K.","year":"2024","journal-title":"Cancer & Metabolism"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.14597"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.1997.38.3.167"},{"key":"e_1_2_9_31_1","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/bph.13751","article-title":"Utilizing Melatonin to Combat Bacterial Infections and Septic Injury","volume":"174","author":"Hu W.","year":"2017","journal-title":"British Journal of Pharmacology"},{"key":"e_1_2_9_32_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2019.113317","article-title":"Aflatoxin B (1) Promotes Autophagy Associated With Oxidative Stress\u2010Related PI3K\/AKT\/mTOR Signaling Pathway in Mice Testis","volume":"255","author":"Huang W.","year":"2019","journal-title":"Environmental Pollution"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.3c08769"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.lab.0000059933.35157.40"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300\u2010483x(83)90121\u2010x"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204\u2010024\u201003799\u2010y"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0967199409990293"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2025.104647"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2024.114335"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010438"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.sc.3102035"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574\u2010018\u20100130\u20101"},{"issue":"3","key":"e_1_2_9_43_1","first-page":"305","article-title":"Aflatoxins as a Cause of Hepatocellular Carcinoma","volume":"22","author":"Kew M. C.","year":"2013","journal-title":"Journal of Gastrointestinal and Liver Diseases"},{"key":"e_1_2_9_44_1","first-page":"111","volume-title":"Histological and Histochemical Methods, Theory and Practice","author":"Kiernan J. A.","year":"2015"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.2298\/aoo0902003s"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1080\/19382014.2020.1783162"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2015.04.029"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5175581"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001810200"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.113225"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgu003"},{"key":"e_1_2_9_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12812"},{"key":"e_1_2_9_53_1","doi-asserted-by":"publisher","DOI":"10.1006\/meth.2001.1262"},{"key":"e_1_2_9_54_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541\u20107786.MCR\u201024\u20100577"},{"key":"e_1_2_9_55_1","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1021\/acs.jafc.3c05776","article-title":"The Ameliorative Role of Lico a on Aflatoxin B1\u2010Triggered Hepatotoxicity Partially by Activating Nrf2 Signal Pathway","volume":"72","author":"Lv H.","year":"2024","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"e_1_2_9_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2012.114"},{"key":"e_1_2_9_57_1","volume-title":"Apoptosis Methods and Protocols. Methods in Molecular Biology","author":"Matassov D.","year":"2004"},{"key":"e_1_2_9_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dnarep.2019.03.004"},{"key":"e_1_2_9_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxicon.2003.10.026"},{"issue":"6","key":"e_1_2_9_60_1","first-page":"417","article-title":"Aflatoxin B1 Induces Apoptosis in Rat Liver, Protective Effect of Melatonin","volume":"22","author":"Meki A. R.","year":"2001","journal-title":"Neuro Endocrinology Letters"},{"key":"e_1_2_9_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.20772"},{"key":"e_1_2_9_62_1","doi-asserted-by":"publisher","DOI":"10.1093\/narmme\/ugae006"},{"key":"e_1_2_9_63_1","first-page":"27","article-title":"Comparison of Antifungal Activities of Zinc, Copper, Cerium Oxide, Silver, Gold, and Selenium Nanoparticles Against Clinical Isolates of Aspergillus","volume":"25","author":"Moghadam S.","year":"2023","journal-title":"Synthesis"},{"key":"e_1_2_9_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2024.153983"},{"key":"e_1_2_9_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcab.2020.101579"},{"key":"e_1_2_9_66_1","doi-asserted-by":"publisher","DOI":"10.9734\/jpri\/2020\/v32i430422"},{"key":"e_1_2_9_67_1","doi-asserted-by":"publisher","DOI":"10.5897\/AJEST2016.2220"},{"issue":"1","key":"e_1_2_9_68_1","article-title":"Antioxidant and Antimicrobial Activities of the Extracts From Different Garcinia Species","volume":"2021","author":"Nguyen N. H.","year":"2021","journal-title":"Evidence\u2010based Complementary and Alternative Medicine"},{"key":"e_1_2_9_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00441434"},{"key":"e_1_2_9_70_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25052849"},{"key":"e_1_2_9_71_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0360864"},{"key":"e_1_2_9_72_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20021918"},{"key":"e_1_2_9_73_1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.4103\/0250-474X.49128","article-title":"Antifungal Activity of Plant Extracts Against Candida Species From Oral Lesions","volume":"70","author":"Prabhakar K.","year":"2008","journal-title":"Indian Journal of Pharmaceutical Sciences"},{"key":"e_1_2_9_74_1","doi-asserted-by":"publisher","DOI":"10.32592\/ARI.2023.78.6.1698"},{"key":"e_1_2_9_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968\u20100004(03)00137\u20103"},{"key":"e_1_2_9_76_1","doi-asserted-by":"publisher","DOI":"10.3390\/ma14020310"},{"key":"e_1_2_9_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12360"},{"issue":"2","key":"e_1_2_9_78_1","first-page":"159","article-title":"Pharmacological Utility of Melatonin in Reducing Oxidative Cellular and Molecular Damage","volume":"56","author":"Reiter R. J.","year":"2004","journal-title":"Polish Journal of Pharmacology"},{"key":"e_1_2_9_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejic.201601185"},{"key":"e_1_2_9_80_1","doi-asserted-by":"publisher","DOI":"10.2478\/s11658\u2010008\u20100036\u20103"},{"issue":"1","key":"e_1_2_9_81_1","doi-asserted-by":"crossref","DOI":"10.3390\/biology11010046","article-title":"Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) for Twelve Antimicrobials (Biocides and Antibiotics) in Eight Strains of Listeria monocytogenes","volume":"11","author":"Rodr\u00edguez\u2010Melc\u00f3n C.","year":"2021","journal-title":"Biology"},{"key":"e_1_2_9_82_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/109.6.958"},{"key":"e_1_2_9_83_1","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1002\/1097-0029(20010215)52:4<430::AID-JEMT1028>3.0.CO;2-3","article-title":"Biology of Transforming Growth Factor \u03b2 in Hepatocarcinogenesis","volume":"52","author":"Rossmanith W.","year":"2001","journal-title":"Microscopy Research and Technique"},{"key":"e_1_2_9_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2019.00467"},{"key":"e_1_2_9_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2018.11.047"},{"issue":"6","key":"e_1_2_9_86_1","first-page":"386","article-title":"Immunomodulatory Effects of Transforming Growth Factor\u2010\u03b2 in the Liver","volume":"3","author":"Schon H.\u2010T.","year":"2014","journal-title":"HepatoBiliary Surgery and Nutrition"},{"key":"e_1_2_9_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10528\u2010017\u20109826\u20105"},{"key":"e_1_2_9_88_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17122124"},{"key":"e_1_2_9_89_1","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1600-079X.2005.00234.x","article-title":"Interactions Between Melatonin and Nicotinamide Nucleotide, NADH Preservation in Cells and in Cell\u2010Free Systems by Melatonin","volume":"39","author":"Tan D. X.","year":"2005","journal-title":"Journal of Pineal Research"},{"key":"e_1_2_9_90_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1620932114"},{"key":"e_1_2_9_91_1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/S0278-6915(01)00131-4","article-title":"Effect of Aflatoxins on Testicular Steroidogenesis and Amelioration by Vitamin E","volume":"40","author":"Verma R.","year":"2002","journal-title":"Food and Chemical Toxicology"},{"key":"e_1_2_9_92_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom15020216"},{"key":"e_1_2_9_93_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8080903"},{"key":"e_1_2_9_94_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2021.4888"},{"key":"e_1_2_9_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.115407"},{"key":"e_1_2_9_96_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.toxicon.2025.108262","article-title":"The Impact of Aflatoxin B1 on Animal Health, Metabolic Processes, Detection Methods, and Preventive Measures","volume":"255","author":"Wang T.","year":"2025","journal-title":"Toxicon"},{"key":"e_1_2_9_97_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox11061082"},{"key":"e_1_2_9_98_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.4c01796"},{"issue":"11","key":"e_1_2_9_99_1","doi-asserted-by":"crossref","DOI":"10.3390\/biom14111460","article-title":"Aflatoxin Exposure\u2010Caused Male Reproductive Toxicity, Molecular Mechanisms, Detoxification, and Future Directions","volume":"214","author":"Ye D.","year":"2024","journal-title":"Biomolecules"},{"key":"e_1_2_9_100_1","doi-asserted-by":"crossref","first-page":"10787","DOI":"10.1021\/acs.jafc.3c02617","article-title":"Aflatoxin B1 Induces Inflammatory Liver Injury via Gut Microbiota in Mice","volume":"71","author":"Ye L.","year":"2023","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"e_1_2_9_101_1","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2024.1444578","article-title":"Melatonin in Animal Husbandry, Functions and Applications","volume":"11","author":"Zhao R.","year":"2024","journal-title":"Frontiers in Veterinary Science"},{"key":"e_1_2_9_102_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/adhm.201100043","article-title":"Highly Potent Bactericidal Activity of Porous Metal\u2013Organic Frameworks","volume":"1","author":"Zhuang W.","year":"2012","journal-title":"Advanced Healthcare Materials"}],"container-title":["Journal of Applied Toxicology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.70341","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jat.70341","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jat.70341","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T06:30:45Z","timestamp":1784269845000},"score":1,"resource":{"primary":{"URL":"https:\/\/analyticalsciencejournals.onlinelibrary.wiley.com\/doi\/10.1002\/jat.70341"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,16]]},"references-count":101,"alternative-id":["10.1002\/jat.70341"],"URL":"https:\/\/doi.org\/10.1002\/jat.70341","archive":["Portico"],"relation":{},"ISSN":["0260-437X","1099-1263"],"issn-type":[{"value":"0260-437X","type":"print"},{"value":"1099-1263","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,16]]},"assertion":[{"value":"2025-11-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"jat.70341"}}